Molecular structure of EW-7197, CAS Number: 1352608-82-2
EW-7197 (CAS 1352608-82-2)
Alternate Names:
Vactosertib EW 7197 TEW-7197
CAS Number:
1352608-82-2
Molecular Weight:
399.40
Molecular Formula:
C22H18FN7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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EW-7197 (CAS 1352608-82-2) References
- EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis. | Son, JY., et al. 2014. Mol Cancer Ther. 13: 1704-16. PMID: 24817629
- EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. | Park, SA., et al. 2015. Cell Mol Life Sci. 72: 2023-39. PMID: 25487606
- Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells. | Naka, K., et al. 2016. Cancer Sci. 107: 140-8. PMID: 26583567
- TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition. | Kim, MJ., et al. 2016. Cell Physiol Biochem. 38: 571-88. PMID: 26845171
- EW-7197, an activin-like kinase 5 inhibitor, suppresses granulation tissue after stent placement in rat esophagus. | Jun, EJ., et al. 2017. Gastrointest Endosc. 86: 219-228. PMID: 28137596
- EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model. | Han, K., et al. 2018. PLoS One. 13: e0192430. PMID: 29447198
- EW-7197, an oral transforming growth factor β type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model. | Tsauo, J., et al. 2018. Surgery. 164: 1100-1108. PMID: 30172565
- EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation. | Binabaj, MM., et al. 2019. J Cell Physiol. 234: 11654-11661. PMID: 30478959
- EW-7197, a Transforming Growth Factor-Beta Type I Receptor Kinase Inhibitor, Ameliorates Acquired Lymphedema in a Mouse Tail Model. | Yoon, SH., et al. 2020. Lymphat Res Biol. 18: 433-438. PMID: 32105567
- EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation. | Ha, KB., et al. 2022. Endocrinol Metab (Seoul). 37: 96-111. PMID: 35255604
- Different routes of administering EW-7197 versus EW-7197⋅HBr for preventing peritoneal adhesion in a rat model. | Zeng, CH., et al. 2023. Surgery. 173: 1008-1014. PMID: 36577598
- The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line. | Konno, T., et al. 2024. Tissue Barriers. 2304443. PMID: 38225862
- EW-7197, transforming growth factor β inhibitor, combined with irreversible electroporation for improving skin wound in a rat excisional model. | Zeng, CH., et al. 2024. Sci Rep. 14: 12779. PMID: 38834729
Inhibitor of:
β ig-h3, ACTR-IA, ACTR-IB, ACTR-IIA, ACTR-IIB, ALK-1, Asporin, BMP-3, BMP2, BMPR-IB, CRIM1, dsg1α, Evx-2, FGL1, FHL-2, GDF-1, GDF-11, GDF-5, GDF-7, GDF-9, GDF-9B, gremlin-2, IL-3Rβ, Inhibin β-E, LOC645781, LOC646862, LOC666145, LRRC32, LRRC70, LRRC72, MAWDBP1, MIXL1, Nodal, NOMO, NOMO1, NOMO2, NOMO3, PLAGL2, PRKRIP1, PTGF-β, Sm B/B′, Smad2, Smad3, Smad4, Smad5, Smad7, SNIP1, SOX (SRY-box transcription factor), Sox-10, SPP24, Tβ-b, TBCK, TBX22, TGF B-1, TGF B3, TGF beta, TGF beta 1, TGF beta RI, TGFα, TGFβ RII, TGIF2LX1, TGIF2LX2, TIMAP, TMEM100, Trichohyalin, Vasorin, and VWC1.Activator of:
ACTR-IIA, ADMP, CHRDL1, DAF-7, DAND5, dpp, FLRG, Inhibin β-B, Lefty-2, LTBP-1, Smad6, SnoN_SnoN2_SnoA, TGF B-1, TGFβ RIII, TGIF, TSC-36, and ZNF512.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EW-7197, 5 mg | sc-507465 | 5 mg | $345.00 |