TFIIA-γ Inhibitors
TFIIA-γ Inhibitors represent a distinct class of chemical compounds that exert their effects by targeting the transcription factor IIA gamma (TFIIA-γ). TFIIA-γ is a crucial component of the transcriptional machinery, playing a pivotal role in the initiation and regulation of gene expression. This class of inhibitors is designed to modulate the activity of TFIIA-γ, a subunit of the transcription factor IIA complex, which interacts with the TATA-binding protein and RNA polymerase II during the formation of the pre-initiation complex. By selectively inhibiting TFIIA-γ, these compounds aim to interfere with the intricate process of transcription initiation, thereby influencing the dynamics of gene regulation at the earliest stages.
TFIIA-γ Inhibitors are characterized by their specific binding affinity to the TFIIA-γ subunit, typically through non-covalent interactions. The molecular architecture of these inhibitors is meticulously crafted to engage with the active site or allosteric pockets of TFIIA-γ, disrupting its functional role in transcriptional activation. This targeted approach distinguishes TFIIA-γ Inhibitors from other classes of compounds and underscores their potential as valuable tools for dissecting the intricate molecular pathways governing gene expression. Researchers are actively exploring the structural nuances and mechanistic insights into how these inhibitors modulate TFIIA-γ activity, paving the way for a deeper understanding of transcriptional regulation and offering potential avenues for further exploration in the field of molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpene triepoxide that inhibits transcription by targeting the XPB subunit of TFIIH, which is part of the transcriptional machinery that includes TFIIA-γ. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a cyclic peptide from the mushroom Amanita phalloides, which inhibits RNA polymerase II, thereby indirectly affecting the proteins that regulate its activity, such as TFIIA-γ. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DrB is a benzimidazole riboside that inhibits transcription initiation by affecting the phosphorylation state of the C-terminal domain of RNA polymerase II, indirectly affecting TFIIA-γ. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and prevents the transcriptional enzyme complex assembly, indirectly influencing TFIIA-γ's role in transcription initiation. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $341.00 $927.00 | 7 | |
ICRF-193 is a bisdioxopiperazine that inhibits DNA topoisomerase II, an enzyme that alters the topologic states of DNA during transcription, thereby affecting transcription factor activities. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases (CDKs) which are involved in the phosphorylation of RNA polymerase II, indirectly affecting transcription initiation and TFIIA-γ. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is an adenosine analog that inhibits RNA synthesis by terminating RNA chain elongation, which can have downstream effects on transcription factors including TFIIA-γ. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin is a platinum-based compound that forms DNA adducts, leading to the inhibition of DNA replication and transcription, indirectly influencing TFIIA-γ function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is an inhibitor of DNA topoisomerase I, which is essential for DNA transcription and replication, indirectly affecting transcription factors like TFIIA-γ. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to G-C rich regions of DNA, inhibiting transcription factors from binding to their recognition sequences and potentially influencing TFIIA-γ. | ||||||