TET3 Inhibitors
TET3 inhibitors are a class of chemical compounds that primarily target the enzyme Ten-Eleven Translocation 3 (TET3). TET3 is a member of the TET family of enzymes, which play a crucial role in the process of DNA demethylation. DNA methylation is a key epigenetic modification involved in gene regulation and cellular differentiation. TET enzymes, including TET3, catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), a critical step in the demethylation process. By inhibiting TET3 activity, TET3 inhibitors interfere with this demethylation process, leading to alterations in gene expression patterns.
The mechanism of action of TET3 inhibitors typically involves binding to the active site of the TET3 enzyme, thereby preventing its interaction with DNA substrates and impeding the conversion of 5mC to 5hmC. This inhibition can result in increased levels of DNA methylation, which can, in turn, affect gene expression and cellular functions. TET3 inhibitors are valuable tools in molecular biology research, as they allow scientists to investigate the specific roles of TET3-mediated DNA demethylation in various biological processes. Additionally, these inhibitors have applications in epigenetic studies and may contribute to a deeper understanding of the complex mechanisms underlying gene regulation and cellular development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine incorporates into DNA and traps DNA methyltransferase, leading to its depletion, which could indirectly affect TET3 activity by altering DNA methylation landscapes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that targets DNA methyltransferases, potentially altering DNA methylation patterns and TET3 expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor, which can lead to changes in DNA methylation status and potentially impact TET3 expression. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine acts to inhibit DNA methyltransferases, leading to DNA demethylation and potential alterations in TET3 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to exhibit DNA demethylating activity, which could impact TET3 expression indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been reported to have demethylating properties, potentially influencing DNA methylation landscapes and TET3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that has been reported to inhibit DNA methyltransferases, potentially affecting TET3 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate, a major component of green tea, has been reported to have DNA demethylating properties, potentially affecting TET3 expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has been reported to inhibit DNA methyltransferases, which could potentially influence TET3 expression. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is a small molecule inhibitor known to inhibit G9a and GLP histone methyltransferases, potentially leading to epigenetic modifications that affect TET3 expression. | ||||||