Tec Activators
The Tec protein, a member of the Tec family of non-receptor tyrosine kinases, plays a pivotal role in regulating various signaling pathways involved in immune cell development, activation, and function. Tec is primarily expressed in hematopoietic cells, including T cells, B cells, and myeloid cells, where it modulates cellular responses to extracellular stimuli such as antigen recognition, cytokine signaling, and cellular adhesion. One of the key functions of Tec is its involvement in B cell receptor (BCR) signaling, where it phosphorylates downstream targets upon BCR engagement, initiating a cascade of intracellular signaling events that ultimately regulate B cell activation, proliferation, and differentiation. Additionally, Tec has been implicated in T cell receptor (TCR) signaling, where it participates in the activation of T cells and the modulation of immune responses against pathogens and foreign antigens. Moreover, Tec also plays a role in other immune cell functions, including mast cell activation, neutrophil migration, and macrophage activation, highlighting its broad impact on the immune system.
Activation of Tec occurs through a series of intricate regulatory mechanisms that govern its catalytic activity and substrate specificity. Upon stimulation of immune cells by extracellular signals, such as antigen binding or cytokine signaling, Tec undergoes conformational changes that expose its catalytic domain, allowing it to phosphorylate downstream signaling molecules. Activation of Tec is often initiated by the recruitment of Tec to cell membrane regions rich in phospholipids and adaptor proteins, where it interacts with other signaling molecules and undergoes phosphorylation by upstream kinases. Furthermore, Tec activation can be modulated by post-translational modifications, such as phosphorylation and protein-protein interactions, which regulate its enzymatic activity and substrate recognition. Overall, the activation of Tec orchestrates a diverse array of cellular responses in immune cells, contributing to the regulation of immune system function and host defense mechanisms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LFM-A13 | 62004-35-7 | sc-203623 sc-203623A | 10 mg 50 mg | $119.00 $670.00 | ||
LFM-A13 inhibits Bruton's tyrosine kinase (BTK), a close relative of Tec. As Tec and BTK share similar signaling pathways, LFM-A13 indirectly enhances Tec activity by suppressing negative regulators, amplifying the signal transduction cascades involving Tec. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $193.00 | 4 | |
Cal-101 inhibits phosphoinositide 3-kinase (PI3K), a regulator of Tec signaling. By disrupting this upstream regulator, Cal-101 indirectly enhances Tec functional activity, leading to amplified signaling cascades involved in Tec-mediated cellular processes. | ||||||
Janex-1 | 202475-60-3 | sc-205354 sc-205354A | 1 mg 5 mg | $36.00 $153.00 | 1 | |
Janex-1 (WHI-P131) is a JAK3 inhibitor, affecting a kinase in close association with Tec. Inhibition of JAK3 by WHI-P131 indirectly enhances Tec activity by preventing negative regulation, resulting in heightened signaling events mediated by Tec. | ||||||
Spebrutinib | 1202757-89-8 | sc-507524 | 100 mg | $375.00 | ||
Spebrutinib, also called AVL-292, is a selective inhibitor of BTK, impacting pathways shared with Tec. Its use enhances Tec functional activity by preventing the inhibitory actions of BTK, leading to the amplification of signaling events mediated by Tec. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a Src family kinase inhibitor, including Tec. By inhibiting Tec and related kinases, PP2 disrupts downstream signaling pathways, indirectly enhancing Tec's functional activity through the relief of inhibitory signals within these cascades. | ||||||
BAY 61-3606 | sc-507485 | 2 mg | $345.00 | 1 | ||
BAY 61-3606 is a selective Syk inhibitor, affecting pathways converging with Tec. Its use indirectly enhances Tec activity by preventing negative regulation through Syk, amplifying signaling cascades involved in Tec-mediated cellular processes. | ||||||
R788 | 901119-35-5 | sc-364597 sc-364597A | 2 mg 50 mg | $405.00 $4000.00 | 2 | |
R788 inhibits BTK, a kinase closely linked to Tec. Through BTK inhibition, Fostamatinib indirectly enhances Tec activity by relieving negative regulation, resulting in intensified signaling events mediated by Tec. | ||||||
R406 | 841290-81-1 | sc-364595 sc-364595A | 2 mg 10 mg | $163.00 $377.00 | 16 | |
R406 is a Syk inhibitor, impacting pathways that intersect with Tec. Its use enhances Tec functional activity by preventing negative regulation through Syk, resulting in the amplification of signaling events mediated by Tec. | ||||||
Acalabrutinib | 1420477-60-6 | sc-507392 | 250 mg | $255.00 | ||
ACP-196 selectively inhibits BTK, closely associated with Tec. Its use enhances Tec functional activity by preventing negative regulation through BTK, resulting in intensified signaling events mediated by Tec. | ||||||