R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, suggesting that they are antigen driven.
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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how long is this product stable for?
Asked by: JoannaT
Thank you for your question. With the recommended storage conditions (-20 °C) we provide a warranty of one year from the date of purchase. For information on the expiry date you can download a lot-specific certificate of analysis or contact our technical service if no lot number is available.
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