R788 CAS: 901119-35-5
MF: C23H26FN6O9P
MW: 580.46
An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling.

R788 (CAS 901119-35-5)

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Synonym: Fostamatinib; (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
Application: An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling
CAS Number: 901119-35-5
Purity: ≥98%
Molecular Weight: 580.46
Molecular Formula: C23H26FN6O9P
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, suggesting that they are antigen driven.

Appearance :
Powder
Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
11671467
SMILES :
CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

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how long is this product stable for?

Asked by: JoannaT
Thank you for your question. With the recommended storage conditions (-20 °C) we provide a warranty of one year from the date of purchase. For information on the expiry date you can download a lot-specific certificate of analysis or contact our technical service if no lot number is available.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06
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