Molecular structure of R788, CAS Number: 901119-35-5
R788 (CAS 901119-35-5)
See product citations (2)
Alternate Names:
Fostamatinib; (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
Application:
R788 is an inhibitor to spleenic kinase-mediated IgG Fc receptor signaling
CAS Number:
901119-35-5
Purity:
≥98%
Molecular Weight:
580.46
Molecular Formula:
C23H26FN6O9P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, suggesting that they are antigen driven.
Inhibitor of:
B-Myb, C3orf37_8430410A17Rik, CD200R4, Enzyme, Fc ε RIγ, FcRH3, Hairy Cell Leukemia Marker, HEATR5A, iASPP, Ig λ, Ig λ chain, IgD, IgD Chain C, IgG light chain, IgH, IgM, Integrin α5, MLLT (Mixed Lineage Leukemia Translocated), NKG2-D, Olfr606, RACK1, RBM3, RGPD7, Sam 68, SKAP55-R, SPBP, Syk, TRBV3, VpreB1, and ZAP-70.Activator of:
BCAP, Bcr, IBtk, Syk, and Tec.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R788, 2 mg | sc-364597 | 2 mg | $405.00 | |||
R788, 50 mg | sc-364597A | 50 mg | $4000.00 |