Molecular structure of LFM-A13, CAS Number: 62004-35-7
LFM-A13 (CAS 62004-35-7)
Alternate Names:
2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Application:
LFM-A13 is a potent and selective inhibitor of Btk
CAS Number:
62004-35-7
Purity:
≥98%
Molecular Weight:
360
Molecular Formula:
C11H8Br2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent and selective inhibitor of Bruton′s tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( which include JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.
LFM-A13 (CAS 62004-35-7) References
1. Mahajan, S., et al. 1999. J. Biol. Chem. 274: 9587-9599.2. Vassilev, A., et al. 1999. J. Biol. Chem. 274: 1646-1656.
3. Crosby, D. and Poole, A.W. 2002. J. Biol. Chem. 277: 9958-9965.
Inhibitor of:
4930570C03Rik, 4932432K03Rik, ANKRD57, ARHGEF9, ASF1A, BCDIN3D, Btk, CCDC68, CCDC95, CD32-C, Cdc5, CHC1-L, CHIC1, EBLN2, EG633057, ELSPBP1, FAM130A1, FAM135A, FAM164B, FAM177A1, GLIPR1, GTPBP2, H-plk, Plk5, ROR1, RUNDC2A, TNIK, V1RC11, V1RC13, ZFP101, ZNF135, ZNF146, ZNF30, ZNF317, and ZZZ3.Activator of:
BRDG1, CARD 11, Kizuna_Plk1s1, and Tec.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LFM-A13, 10 mg | sc-203623 | 10 mg | $119.00 | |||
LFM-A13, 50 mg | sc-203623A | 50 mg | $670.00 |