TCP10L Inhibitors
TCP10L inhibitors are a class of chemical compounds designed to target and inhibit the activity of the TCP10L protein, a member of the TCP-1/cpn60 chaperonin family. TCP10L, or T-complex protein 10-like, is believed to be involved in protein folding and complex assembly processes within cells. Chaperonins, like TCP10L, play a critical role in ensuring that proteins achieve and maintain their correct three-dimensional structure, which is essential for proper cellular function. TCP10L is thought to participate in the folding of specific protein substrates or in the stabilization of protein complexes within specialized cellular compartments. By inhibiting TCP10L, these compounds can disrupt the proper folding and assembly of target proteins, leading to alterations in cellular functions that depend on these correctly folded proteins.
Inhibitors of TCP10L provide valuable tools for studying the molecular mechanisms underlying protein folding and the maintenance of protein homeostasis in cells. By blocking the activity of TCP10L, researchers can explore how impaired chaperonin function affects protein stability, aggregation, and degradation. This inhibition can also reveal insights into the broader role of chaperonins in various cellular processes, such as stress responses, protein quality control, and the assembly of multi-protein complexes. TCP10L inhibitors allow scientists to dissect the specific contributions of this chaperonin in these processes, offering a deeper understanding of how cells manage their proteome under normal and stress conditions. Overall, the study of TCP10L inhibitors contributes to our understanding of the complex networks that govern protein folding, assembly, and cellular proteostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may activate specific retinoic acid receptors that downregulate TCP10L gene transcription directly or through interference with cofactors essential for its expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could inhibit the expression of TCP10L by hindering the activity of DNA methyltransferases, leading to hypermethylation of the TCP10L gene promoter. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may decrease TCP10L expression by inhibiting the activation of transcription factors that are upstream regulators of the TCP10L gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might suppress TCP10L by enhancing the deacetylation of histones associated with the TCP10L promoter region, which tightens chromatin structure and lowers gene accessibility. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could reduce TCP10L expression by activating the Nrf2 pathway, which may lead to a repressive chromatin environment around the TCP10L gene locus. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin may indirectly decrease the expression of TCP10L by activating AMP-activated protein kinase (AMPK), which can result in a cellular energy state that suppresses the translation of various genes, including potentially TCP10L. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may downregulate TCP10L expression by inhibiting the phosphorylation of kinases involved in transcriptional activation, leading to reduced promoter activity of the gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 might decrease TCP10L gene expression by inhibiting phosphoinositide 3-kinases, thereby altering the AKT signaling pathway and reducing transcriptional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could inhibit the expression of TCP10L by blocking the mammalian target of rapamycin (mTOR) pathway, which is involved in the regulation of mRNA translation and cell growth. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate could suppress TCP10L expression by inhibiting histone deacetylases, leading to increased histone acetylation and a repressive effect on gene transcription. | ||||||