TBPL2 Activators
The protein TBPL2, also known as TATA box-binding protein-like 2, serves as a transcription factor involved in the regulation of gene expression. TBPL2 is structurally similar to the TATA-binding protein (TBP) and is part of the TBP family of proteins. While TBP is primarily associated with the recognition of TATA boxes in gene promoters, TBPL2 exhibits broader DNA-binding specificity, recognizing diverse promoter sequences. TBPL2 plays a crucial role in the assembly of the pre-initiation complex (PIC) at gene promoters, facilitating the recruitment of RNA polymerase II and other transcriptional machinery components. Moreover, TBPL2 is implicated in the regulation of gene expression programs associated with various cellular processes, including development, differentiation, and stress responses.
Activation of TBPL2 involves intricate signaling pathways and regulatory mechanisms that modulate its transcriptional activity. Several upstream regulators influence TBPL2 expression levels and function. For instance, signaling pathways activated by growth factors, hormones, or environmental cues can impact TBPL2 activity by regulating its expression or post-translational modifications. Additionally, coactivators and chromatin-modifying enzymes may interact with TBPL2 to enhance its DNA-binding affinity or stabilize its association with gene promoters. Moreover, intracellular signaling cascades mediated by protein kinases or phosphatases can modulate TBPL2 activity through direct phosphorylation or dephosphorylation events. Understanding the molecular mechanisms governing TBPL2 activation is essential for unraveling its roles in gene regulation and cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can lead to the activation of PKA. PKA, in turn, can phosphorylate various transcription factors and coactivators, potentially enhancing the transcriptional activity of TBPL2 by promoting its interaction with these factors. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase, which may influence the phosphorylation state of transcription machinery, thereby potentially increasing the activity of TBPL2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling pathways. PKC can modify transcription factors and other proteins that interact with TBPL2, potentially enhancing TBPL2's role in transcription regulation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol acts as an agonist of beta-adrenergic receptors, leading to increased cAMP and activation of PKA. PKA may phosphorylate proteins associated with the transcription machinery, which could enhance TBPL2's transcriptional activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can result in phosphorylation events that enhance TBPL2's interaction with transcriptional coactivators, thereby increasing its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, potentially leading to the activation of calcium-dependent protein kinases. These kinases could modify transcriptional regulators that interact with TBPL2, enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit various kinases, potentially decreasing competitive inhibition on transcription factors or coactivators that interact with TBPL2, leading to an enhancement of TBPL2's transcriptional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is another cell-permeable analog of cAMP that activates PKA. PKA-mediated phosphorylation events may enhance the transcriptional activity of TBPL2 by promoting its association with other proteins in the transcription machinery. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Inhibition of these phosphatases can lead to increased phosphorylation of transcription factors and associated proteins, potentially increasing the transcriptional activity of TBPL2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a specific inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, it may enhance the phosphorylation state of proteins involved in the transcriptional regulation that interact with TBPL2, thereby enhancing TBPL2's activity. | ||||||