TBC1D3C Activators
TBC1D3C, a member of the TBC1 domain family, plays a crucial role in cellular processes such as vesicle trafficking, cell signaling, and membrane dynamics. Specifically, TBC1D3C functions as a GTPase-activating protein (GAP) involved in regulating the activity of Rab GTPases, which are essential for vesicle trafficking and membrane trafficking events within cells. By modulating the activity of Rab GTPases, TBC1D3C influences various cellular processes, including endocytosis, exocytosis, and intracellular vesicle transport, ultimately contributing to the maintenance of cellular homeostasis and signaling.
Activation of TBC1D3C can be achieved through the modulation of several cellular pathways. Compounds such as luteolin, quercetin, and EGCG indirectly activate TBC1D3C by influencing signaling cascades such as the PI3K/Akt, mTOR, and AMPK pathways. These compounds inhibit key signaling molecules within these pathways, thereby relieving the inhibitory effect on TBC1D3C and promoting its activation. Additionally, other chemicals like curcumin, genistein, and resveratrol indirectly activate TBC1D3C by targeting pathways such as NF-κB, Wnt/β-catenin, and Nrf2, respectively. Through modulation of these pathways, these compounds enhance the activity of TBC1D3C, contributing to cellular processes regulated by this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin activates TBC1D3C by inhibiting the PI3K/Akt signaling pathway. It directly binds to and inhibits PI3K, leading to decreased Akt phosphorylation. This inhibition relieves the suppressive effect of Akt on TBC1D3C, allowing for its activation. Thus, luteolin indirectly activates TBC1D3C by modulating the PI3K/Akt pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates TBC1D3C through inhibition of the mTOR signaling pathway. By directly inhibiting mTOR, quercetin reduces the phosphorylation of downstream targets, including S6K and 4EBP1. This inhibition of mTOR signaling alleviates the negative regulation of TBC1D3C, leading to its activation. Hence, quercetin acts as an indirect activator of TBC1D3C via the mTOR pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates TBC1D3C by modulating the AMPK pathway. It stimulates AMPK activation, resulting in the inhibition of mTOR signaling. This inhibition relieves the suppressive effect of mTOR on TBC1D3C, thereby facilitating its activation. Consequently, EGCG indirectly activates TBC1D3C through AMPK-mediated regulation of the mTOR pathway. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates TBC1D3C by suppressing the MAPK/ERK pathway. It inhibits the activation of ERK, which leads to decreased phosphorylation of downstream effectors. This inhibition alleviates the inhibitory effect of ERK on TBC1D3C, resulting in its activation. Therefore, berberine functions as an indirect activator of TBC1D3C via modulation of the MAPK/ERK pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates TBC1D3C by inhibiting the NF-κB signaling pathway. It blocks the activation of NF-κB, thereby reducing the transcription of inflammatory genes. This inhibition indirectly activates TBC1D3C by preventing NF-κB-mediated suppression. Thus, curcumin serves as an indirect activator of TBC1D3C through modulation of the NF-κB pathway. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates TBC1D3C through inhibition of the Wnt/β-catenin pathway. It disrupts the interaction between Wnt ligands and their receptors, leading to decreased β-catenin stabilization and transcriptional activity. This inhibition relieves the inhibitory effect of β-catenin on TBC1D3C, resulting in its activation. Therefore, genistein acts as an indirect activator of TBC1D3C via modulation of the Wnt/β-catenin pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates TBC1D3C by modulating the AMPK pathway. It activates AMPK, which inhibits mTOR signaling. This inhibition relieves the suppressive effect of mTOR on TBC1D3C, leading to its activation. Thus, resveratrol indirectly activates TBC1D3C through AMPK-mediated regulation of the mTOR pathway. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin activates TBC1D3C by inhibiting the PI3K/Akt signaling pathway. It directly inhibits PI3K, leading to decreased Akt phosphorylation. This inhibition relieves the suppressive effect of Akt on TBC1D3C, allowing for its activation. Hence, apigenin functions as an indirect activator of TBC1D3C by modulating the PI3K/Akt pathway. | ||||||
Diosmin | 520-27-4 | sc-204728 sc-204728A | 5 g 25 g | $58.00 $114.00 | 2 | |
Diosmin activates TBC1D3C by suppressing the NF-κB signaling pathway. It inhibits the activation of NF-κB, thereby reducing the expression of pro-inflammatory genes. This inhibition indirectly activates TBC1D3C by preventing NF-κB-mediated suppression. Thus, diosmin serves as an indirect activator of TBC1D3C through modulation of the NF-κB pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates TBC1D3C by modulating the Nrf2 pathway. It promotes the nuclear translocation of Nrf2, leading to increased expression of antioxidant enzymes. This activation indirectly stimulates TBC1D3C by enhancing cellular antioxidant defenses. Therefore, sulforaphane acts as an indirect activator of TBC1D3C through Nrf2-mediated regulation. | ||||||