Diosmin CAS: 520-27-4
MF: C28H32O15
MW: 608.5
A flavonoid glycoside that reduces venous hyperpressure.

Diosmin (CAS 520-27-4)

Diosmin | CAS 520-27-4 is rated 5.0 out of 5 by 1.
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Alternate Names: 3',5,7-Trihydroxy-4'-methoxyflavone 7-rutinoside
Application: Diosmin is a flavonoid glycoside that reduces venous hyperpressure
CAS Number: 520-27-4
Purity: ≥95%
Molecular Weight: 608.5
Molecular Formula: C28H32O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyperpressure. Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.


References

Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids: W. Thanapongsathorn & T. Vajrabukka; Dis. Colon Rectum 35, 1085 (1992) Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines: E. Sher, et al.; Pharmacol. Res. 26, 395 (1992) Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils: B. Cypriani, et al.; Biochem. Pharmacol. 45, 1531 (1993) Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein: J.P. Savineau & R. Marthan; Br. J. Pharmacol. 111, 978 (1994) Venous elasticity after treatment with Daflon 500 mg: V. Ibegbuna, et al.; Angiology 48, 45 (1997) Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice: M. Yang, et al.; Int. J. Cancer 73, 719 (1997) Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity: H.P. Ciolino, et al.; Cancer Res. 58, 2754 (1998) Modulation by phytochemicals of cytochrome P450-linked enzyme activity: R.W. Teel & H. Huynh; Cancer Lett. 133, 135 (1998) Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin: M.F. Melzig & R. Loose; Pharmazie 54, 298 (1999) Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS: M.E. Crespo, et al.; Planta Med. 65, 651 (1999) Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells: Q. Zheng, et al.; J. Cancer Res. Clin. Oncol. 128, 539 (2002) The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury: M. Pehlivan, et al.; Acta Chir. Belg. 104, 715 (2004) Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin: C. Martinez Conesa, et al.; J. Agric. Food Chem. 53, 6791 (2005)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
274° C (dec.)
Boiling Point :
~926.8° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
Optical Activity :
α20/D -121°±5°, c = 0.5 in 0.1 mol/l NaOH
pK Values :
pKa: 6.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5281613
Merck Index :
14: 3297
MDL Number :
MFCD00009772
EC Number :
208-289-7

Download SDS (MSDS)

Certificate of Analysis

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Diosmin (CAS 520-27-4)  Product Citations

See how others have used Diosmin (CAS 520-27-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 32061149  Environ. Toxicol.

Citations 1 to 1 of 1 total

What is the appearance of the chemical?

Asked by: two2igm05
Thank you for your question. The compound, sc-204728, is provided as a greyish-yellow or light-yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected] or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2020-06-28
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Rated 5 out of 5 by from Imam F; et al Imam F; et al. (PubMed ID: 26361726) determined that Diosmin exhibited a protective effect in LPS-induced lung injuries in mice. -SCBT Publication Review
Date published: 2015-06-23
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