TBC1D3 Inhibitors
TBC1D3 inhibitors represent a class of chemical compounds designed to modulate cellular processes by targeting the TBC1D3 protein. TBC1D3, standing for TBC1 domain family member 3, is a member of the Tre-2/Bub2/Cdc16 (TBC) domain-containing proteins that play crucial roles in cellular functions. The TBC1D3 protein, specifically, is known for its involvement in endocytic trafficking and regulation of cellular vesicle transport. In normal cellular physiology, TBC1D3 participates in modulating the trafficking of vesicles through its interaction with Rab GTPases, key regulators of membrane trafficking pathways. By inhibiting TBC1D3, these inhibitors potentially disrupt the finely tuned balance of vesicle transport, influencing cellular homeostasis.
TBC1D3 inhibitors are designed to interact with the active sites or binding domains of the TBC1D3 protein, preventing its normal function. The development of these inhibitors often involves a meticulous understanding of the three-dimensional structure of TBC1D3 and the identification of key molecular interactions that can be exploited for inhibitory purposes. The chemical modifications introduced in these inhibitors are aimed at achieving high specificity and affinity for the TBC1D3 target, ensuring effective interference with its cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibitor of PI3K, a kinase involved upstream of Rab5, potentially altering the activity of TBC1D3 indirectly by modulating endocytic trafficking. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor that can affect the upstream signaling of Rab5, and thereby influence TBC1D3's GAP activity. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
Inhibits Rac1, a small GTPase, which could indirectly affect the endocytic pathways where TBC1D3 operates. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
A selective inhibitor of Cdc42, another GTPase that may interact with the endocytic pathway, thus possibly altering TBC1D3 function. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
Inhibits cytohesins, which indirectly modulate small GTPase signaling, potentially affecting TBC1D3's role in endocytosis. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
A Rac1 inhibitor that could affect actin cytoskeleton dynamics, thus possibly influencing TBC1D3's associated pathways. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
A Cdc42 inhibitor that could disrupt actin polymerization and indirectly impact TBC1D3's function. | ||||||
2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid | 314042-01-8 | sc-503400 | 10 mg | $300.00 | ||
A selective inhibitor of Rab7, which is another Rab GTPase that might intersect with TBC1D3's regulatory pathways. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, a GTPase that mediates vesicle scission, potentially influencing the trafficking processes TBC1D3 is involved in. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $250.00 | ||
Another dynamin inhibitor that can affect endocytosis and potentially impact TBC1D3's function by altering vesicle trafficking. | ||||||