TBC1D21 Activators
TBC1D21 activators constitute a unique class of chemical compounds that target and modulate the function of the protein TBC1 domain family member 21 (TBC1D21). The TBC1D21 protein is part of a larger family of proteins characterized by the presence of a TBC (Tre-2/Bub2/Cdc16) domain, which typically confers a role in the regulation of cell signaling pathways, particularly those involving membrane trafficking and small GTPases such as Rab proteins. Activators of TBC1D21 are designed to interface with this protein in a way that modulates its activity, potentially altering its interaction with other cellular components and affecting the intrinsic GTPase activity which is central to its function.
The specificity of TBC1D21 activators is grounded in their molecular design, which allows them to selectively bind to TBC1D21, thus affecting its regulatory function. The biochemical interaction between TBC1D21 and its activators is a prime example of targeted molecular modulation within the complex network of cellular signaling. These compounds can affect the protein's ability to catalyze the hydrolysis of GTP bound to Rab GTPases, which in turn can influence various cellular processes. The activity of TBC1D21 is integral to the control of vesicle trafficking, a critical component of intracellular transport mechanisms that maintain homeostasis within the cell. By activating TBC1D21, these compounds have the potential to impact the dynamics of membrane-bound vesicles, which are pivotal in the shuttling of proteins and lipids throughout the cell, and are essential for the proper function of intracellular compartments. The precise molecular interactions and the resulting biochemical outcomes define this class of chemicals as a significant point of interest within the field of molecular biology and biochemistry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) within the cell. Elevated cAMP activates PKA (Protein Kinase A), which can phosphorylate a variety of substrates, including proteins that can interact with or modify the activity of TBC1D21. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, enzymes responsible for the breakdown of cAMP. By preventing cAMP degradation, IBMX indirectly sustains PKA activation, which could enhance TBC1D21 activity through downstream effects on cellular signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can inhibit certain protein kinases. By modulating kinase activity, EGCG may influence signaling pathways that indirectly enhance the activity of TBC1D21. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate sphingosine-1-phosphate receptors, leading to downstream effects that may include the activation of signaling cascades that influence the activity of TBC1D21. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). Activated PKC may affect signaling pathways or proteins that modulate the functional activity of TBC1D21. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as an ionophore that facilitates the influx of calcium ions. Increased intracellular calcium can activate calcium-dependent signaling pathways, potentially enhancing the activity of TBC1D21. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By blocking PI3K activity, it modulates downstream AKT signaling, which could indirectly affect the functional pathways involving TBC1D21. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, components of the MAPK pathway. Inhibition of this pathway can lead to compensatory effects in other signaling cascades that may enhance TBC1D21 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Through the selective inhibition of p38, it can indirectly influence signaling pathways that enhance the activity of TBC1D21. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins, which can indirectly enhance the activity of TBC1D21 through altered signaling dynamics. | ||||||