TAP Inhibitors
TAP inhibitors constitute a diverse group of compounds that exert their regulatory influence on the Transporter associated with Antigen Processing (TAP) through various cellular pathways. These compounds, exemplified by the selected chemicals in the tabulated form, showcase the intricate interplay between TAP and distinct signaling cascades, offering valuable insights into potential avenues for targeted modulation. One notable category includes inhibitors that act indirectly by perturbing purinergic signaling pathways. Suramin, for instance, competes with ATP for binding to purinergic receptors, disrupting calcium signaling and subsequently impacting TAP activity. This highlights the integration of nucleotide signaling in TAP regulation. Additionally, the indirect modulation of TAP by compounds targeting redox balance is exemplified by Piperlongumine. By inducing reactive oxygen species production, Piperlongumine influences cellular redox homeostasis, indirectly affecting TAP function. These compounds collectively underscore the complexity of TAP regulation and provide tools to dissect specific pathways governing its expression and activity.
Furthermore, inhibitors targeting mTOR, like Rapamycin, illuminate the connection between TAP and cellular growth. Rapamycin's inhibition of mTOR indirectly impacts TAP function, emphasizing the intersection between immune responses and cellular metabolic processes. TAP inhibitors, including LY294002, that interfere with PI3K/Akt signaling provide additional insights into the modulation of TAP by pathways involved in cell survival and proliferation. The indirect inhibition of TAP through stress-related signaling pathways is exemplified by SP600125, an inhibitor of JNK, emphasizing the influence of cellular stress responses on TAP activity. Additionally, compounds like SB-216763 that target the Wnt signaling pathway showcase the integration of developmental signaling in TAP regulation. Epigenetic modulation represented by SP2509, an LSD1 inhibitor, unveils the potential influence of chromatin remodeling on TAP expression. This highlights the role of epigenetic modifications in shaping the TAP landscape. Metabolic modulation through AMPK activation, as demonstrated by A769662, adds another layer of complexity to TAP regulation, linking TAP function to cellular energy homeostasis. In conclusion, TAP inhibitors, as exemplified by the diverse chemical entities discussed, provide a comprehensive toolkit for deciphering the intricate regulatory networks governing TAP expression and activity.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a polyanionic compound known to inhibit TAP indirectly by interfering with nucleotide binding. It acts as a purinergic antagonist, disrupting purinergic signaling pathways. Specifically, suramin competes with ATP for binding to purinergic receptors, such as P2X and P2Y receptors. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine, a natural alkaloid, acts as an indirect inhibitor of TAP by modulating cellular redox balance. It induces reactive oxygen species (ROS) production by inhibiting the enzyme glutathione S-transferase P1-1. The increased ROS levels influence the cellular redox state, subsequently activating stress-related pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 is a pyridinyl imidazole compound that acts as an indirect inhibitor of TAP by targeting the p38 MAPK signaling pathway. It selectively inhibits the p38 MAPK enzyme, a key regulator of inflammatory responses. Since TAP expression and activity can be modulated by inflammatory signals, SB-203580 indirectly impacts TAP function by disrupting the signaling cascade downstream of p38 MAPK. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a fungal metabolite that serves as an indirect inhibitor of TAP by targeting the phosphoinositide 3-kinase (PI3K) signaling pathway. By irreversibly inhibiting PI3K, wortmannin disrupts downstream signaling cascades, including Akt activation. TAP expression and function are known to be modulated by the PI3K/Akt pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a synthetic inhibitor targeting phosphoinositide 3-kinase (PI3K) and serves as an indirect inhibitor of TAP. By inhibiting PI3K, LY294002 disrupts downstream signaling pathways, including Akt activation. TAP expression and function are tightly regulated by the PI3K/Akt pathway. Therefore, LY294002 influences TAP activity indirectly by modulating this critical signaling cascade. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an immunosuppressive macrolide, acts as an indirect inhibitor of TAP by targeting the mTOR signaling pathway. By forming a complex with FKBP12, rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. TAP expression and activity are linked to cellular growth and metabolic processes regulated by mTOR. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a potent and selective inhibitor of MEK1, functioning as an indirect inhibitor of TAP through its modulation of the MAPK/ERK signaling pathway. TAP expression is tightly regulated by the MAPK/ERK pathway, and PD98059 disrupts this signaling cascade by specifically inhibiting MEK1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a selective inhibitor of JNK, acts as an indirect inhibitor of TAP by targeting the JNK signaling pathway. TAP expression and activity can be modulated by stress-related signaling pathways, including JNK. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB-216763 is a selective GSK-3 inhibitor that serves as an indirect inhibitor of TAP by modulating the Wnt signaling pathway. TAP expression is known to be influenced by the Wnt pathway, and SB-216763 disrupts this signaling cascade by inhibiting GSK-3. | ||||||
SP2509 | 1423715-09-6 | sc-492604 | 5 mg | $284.00 | ||
SP2509 is a small-molecule inhibitor of histone demethylase LSD1, acting as an indirect inhibitor of TAP through epigenetic modulation. LSD1 is involved in chromatin remodeling and transcriptional regulation, and its inhibition by SP2509 can influence the expression of genes, including TAP. | ||||||