Talanin Inhibitors
Talanin inhibitors are a class of chemical compounds that specifically target and block the function of talin, a key cytoskeletal protein involved in integrin-mediated cell adhesion and signal transduction. Talin plays a crucial role in linking integrins, which are transmembrane receptors, to the actin cytoskeleton, thereby regulating cell adhesion, migration, and mechanical stability. By binding to integrins, talin helps activate them, facilitating the interaction of cells with the extracellular matrix (ECM) and transmitting signals from the ECM to the cell interior. This process is essential for various cellular functions such as motility, survival, and proliferation. Inhibitors of talin disrupt these integrin-cytoskeleton linkages, thus impairing the cell's ability to adhere and respond to mechanical signals from its environment.
Talanin inhibitors are critical tools for understanding the complex mechanisms of cell adhesion and motility. By inhibiting talin, researchers can explore how cells lose their ability to attach to the ECM, which in turn impacts cellular processes like migration, shape, and mechanical force transmission. This allows for a deeper investigation into the molecular pathways that govern integrin activation and how cells dynamically interact with their surroundings. Additionally, talin inhibitors offer insights into the feedback loops between mechanical forces, cytoskeletal tension, and signal transduction pathways, which are vital for processes like cell spreading, migration, and tissue organization. Through these studies, talin inhibitors help clarify the role of cytoskeletal proteins in regulating cellular architecture and responses to mechanical stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $94.00 $122.00 | ||
Nutlin-3 may inhibit zinc finger protein 365 expression by disrupting the interaction between MDM2 and p53, leading to p53-mediated transcriptional activation that could suppress ZNF365 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 may inhibit zinc finger protein 365 expression by inhibiting the proteasome, leading to the accumulation of proteins that would otherwise be degraded, including ZNF365, thus reducing its expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib may inhibit zinc finger protein 365 expression by inhibiting the proteasome, which could lead to the accumulation of ZNF365 and potentially downregulate its expression through feedback mechanisms. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib may inhibit zinc finger protein 365 expression by inhibiting JAK1 and JAK2, which are involved in signaling pathways that regulate gene expression, including the expression of ZNF365. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide may inhibit zinc finger protein 365 expression by modulating cytokine levels and NF-κB activity, which can influence the expression of genes including ZNF365. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 may inhibit zinc finger protein 365 expression by inhibiting PI3K signaling pathway, which is involved in regulating gene expression including the expression of ZNF365. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 may inhibit zinc finger protein 365 expression by inhibiting p38 MAPK signaling pathway, which regulates gene expression including the expression of ZNF365. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
5-Iodotubercidin may inhibit zinc finger protein 365 expression by inhibiting adenosine kinase, leading to decreased adenosine levels, which can modulate gene expression including ZNF365. | ||||||
AZD1480 | 935666-88-9 | sc-364735 sc-364735A | 5 mg 50 mg | $124.00 $1072.00 | 11 | |
AZD1480 may inhibit zinc finger protein 365 expression by inhibiting JAK1 and JAK2, which are involved in signaling pathways that regulate gene expression, including the expression of ZNF365. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin may inhibit zinc finger protein 365 expression by inhibiting PI3K signaling pathway, which regulates various cellular processes including protein expression, including ZNF365. | ||||||