Molecular structure of (+)-Nutlin-3, CAS Number: 675576-97-3
(+)-Nutlin-3 (CAS 675576-97-3)
Alternate Names:
Nutlin 3b
Application:
(+)-Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction
CAS Number:
675576-97-3
Purity:
≥98%
Molecular Weight:
581.5
Molecular Formula:
C30H30Cl2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction.3 (+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-Mdm2 interaction than (−)-nutlin-3, demonstrating an IC50 value of 13.6 µM.3 This inactive enantiomer can serve as a useful control for non-Mdm2 related cellular activities.
(+)-Nutlin-3 (CAS 675576-97-3) References
- Recent advances in the therapeutic perspectives of Nutlin-3. | Secchiero, P., et al. 2011. Curr Pharm Des. 17: 569-77. PMID: 21391907
- Nanoparticles loaded with Nutlin-3 display cytotoxicity towards p53(wild-type) JVM-2 but not towards p53(mutated) BJAB leukemic cells. | Voltan, R., et al. 2013. Curr Med Chem. 20: 2712-22. PMID: 23627936
- Sequential cancer mutations in cultured human intestinal stem cells. | Drost, J., et al. 2015. Nature. 521: 43-7. PMID: 25924068
- Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells. | Wu, Q., et al. 2016. Oncol Rep. 36: 1325-32. PMID: 27430152
- Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53. | He, T., et al. 2018. Pathol Oncol Res. 24: 75-81. PMID: 28341911
- Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins. | Wang, XH., et al. 2017. Tumour Biol. 39: 1010428317701638. PMID: 28618955
- Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis. | Lee, DM., et al. 2017. Exp Mol Med. 49: e365. PMID: 28798402
- Synergistic effect of nutlin-3 combined with aspirin in hepatocellular carcinoma HepG2 cells through activation of Bcl-2/Bax signaling pathway. | Miao, R., et al. 2018. Mol Med Rep. 17: 3735-3743. PMID: 29286113
- The effects of Nutlin-3 on morphology, cellular proliferation, and apoptosis in rat primary mesenchymal stem cells. | Bajelan, B., et al. 2019. J Cell Physiol. 234: 11424-11430. PMID: 30478967
- Nutlin-3-Induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis Through Repression of Akt1/Wnt Signaling. | Wang, M., et al. 2019. Oncol Res. 27: 987-995. PMID: 30832755
- Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3. | Wu, L., et al. 2019. Analyst. 144: 3959-3966. PMID: 31134974
- A novel anti-cancer mechanism of Nutlin-3 through downregulation of Eag1 channel and PI3K/AKT pathway. | Wang, X., et al. 2019. Biochem Biophys Res Commun. 517: 445-451. PMID: 31378368
- Resistance of human primary mesenchymal stem cells to cytotoxic effects of nutlin-3 in vitro. | Bajelan, B., et al. 2020. J Cell Biochem. 121: 788-796. PMID: 31452266
Inhibitor of:
D4Wsu53e, EG546638, EG625480, FAM136A, Hemoglobin δ, Histone cluster 3 H2A, LMO1, MYBBP1A, OTTMUSG00000010747, OTTMUSG00000016784, p53, Pericentrin 2, RFWD3, RNF215, SAMD4A, Talanin, Taok3, TSGA10, and TTC30A2.Activator of:
BC053393, EG625480, and RIP/Rab.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Nutlin-3, 500 µg | sc-222085 | 500 µg | $94.00 | |||
(+)-Nutlin-3, 1 mg | sc-222085A | 1 mg | $122.00 |