TAG Activators
Chemical activators of TAG can influence its activity through various intracellular signaling pathways and molecular mechanisms. Resveratrol, a polyphenol found in grape skins, can activate TAG by stimulating the SIRT1 pathway, which leads to the deacetylation of proteins involved in NF-κB signaling. This activation cascade ultimately enhances NF-κB signaling, which is closely associated with the functional activities of TAG. Similarly, curcumin engages with NF-κB, a pivotal player in inflammatory responses, to activate TAG. The engagement is facilitated through the transcriptional activation of NF-κB. Sulforaphane, another naturally occurring compound, activates TAG by stimulating the Nrf2 pathway, a key regulatory pathway in oxidative stress response. The interplay between oxidative stress and NF-κB signaling can lead to the activation of TAG.
Furthermore, capsaicin can activate TAG through the modulation of intracellular calcium levels. By activating TRPV1 channels, capsaicin facilitates an influx of calcium ions, which then activate calcium-dependent kinases, leading to the phosphorylation and consequent activation of TAG. Forskolin, by increasing intracellular cAMP, activates PKA, which also targets proteins in the NF-κB pathway, thereby influencing TAG's activity. Compounds like epigallocatechin gallate and quercetin can affect TAG by modulating the NF-κB pathway, either by inhibiting NF-κB activation or by modulating kinase signaling pathways that enhance NF-κB activation. Anandamide activates TAG through cannabinoid receptor-mediated modulation of intracellular signaling pathways, such as PI3K/Akt, which are known to activate NF-κB. Spermidine, through the induction of autophagy, influences the NF-κB signaling pathway, which is closely linked to the functional regulation of TAG. Other compounds like kaempferol and piperine can also activate TAG by affecting the phosphorylation state of proteins within the NF-κB pathway. Lastly, genistein can influence TAG activity through its ability to activate estrogen receptors, which can interact with NF-κB signaling pathways, leading to the activation of TAG.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which can lead to deacetylation of proteins involved in the regulation of NF-κB signaling, a pathway known to be influenced by TAG. Activation of SIRT1 by resveratrol can, therefore, result in the activation of TAG through enhanced NF-κB signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can activate the transcription factor NF-κB, which plays a role in the inflammatory response and is a known pathway that TAG is involved in. Through the activation of NF-κB, Curcumin can lead to the functional activation of TAG. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is involved in the cellular response to oxidative stress. Since TAG is associated with the NF-κB signaling pathway, which can be influenced by oxidative stress, the activation of Nrf2 by Sulforaphane can lead to the downstream activation of TAG. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 channels, leading to an influx of calcium ions. This increase in intracellular calcium can activate calcium-dependent kinases, which in turn can activate TAG through phosphorylation mechanisms that are part of the protein's functional regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate is known to inhibit NF-κB activation by preventing its translocation to the nucleus. This perturbation within the NF-κB pathway can activate compensatory mechanisms that can lead to the activation of TAG, as TAG is involved in the NF-κB signaling pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is an antioxidant that can modulate kinase signaling pathways. By influencing these pathways, quercetin can enhance the activation of NF-κB. Since TAG is part of the NF-κB signaling cascade, the activation of this pathway by quercetin can lead to the functional activation of TAG. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine can induce autophagy through inhibition of the acetyltransferase EP300. Autophagy has been shown to regulate the NF-κB signaling pathway by degrading IκB kinase, which could lead to the activation of TAG as it is involved in the NF-κB signaling pathway. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol can inhibit the phosphorylation of IκB, an inhibitor of NF-κB, leading to the activation of NF-κB. By activating NF-κB, kaempferol can subsequently activate TAG, which is functionally related to this pathway. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine has been shown to enhance the phosphorylation of proteins in the NF-κB pathway, which could lead to the activation of TAG given its role in this signaling cascade. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can activate estrogen receptors, which may have cross-talk with NF-κB signaling pathways. Through this cross-talk and subsequent signaling, genistein can lead to the activation of TAG, which is implicated in NF-κB mediated signaling processes. | ||||||