T2R16 Activators
T2R16 Activators comprise a diverse array of chemical compounds that initiate a series of intracellular events resulting in the activation of the T2R16 receptor, which is integral to the detection of bitter compounds. Denatonium Benzoate, recognized as one of the most bitter substances, directly stimulates T2R16, leading to an increase in intracellular calcium critical for taste signaling. Chloroquine and Quinine, both with antimalarial properties and bitter taste profiles, activate T2R16 in a similar fashion, causing gustducin activation and the release of calcium from intracellular stores. Artificial sweetener Saccharin, at high concentrations, and Propylthiouracil (PROP), both activate T2R16, triggering G-protein-mediated signaling cascades that result in TRPM5 channel opening and cell depolarization. Caffeine, a common bitter compound, and Nicotine, an alkaloid, also target T2R16, enhancing the receptor's calcium signaling pathway essential for taste perception.
Additionally, Magnesium Sulfate and Colchicine engage T2R16 and are known to induce G-protein signaling, crucial for the receptor's function in bitter taste transduction. Allyl Isothiocyanate, found in mustard oil, and Phenylthiocarbamide (PTC), a compound with variable taste sensitivity in the population, both activate T2R16, promoting G-protein coupled receptor pathways and increased intracellular calcium. Naringin, a bitter-tasting flavonoidfound in grapefruits, activates T2R16, leading to the enhancement of similar taste receptor cell signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
A known bitter compound that directly activates T2R16, a bitter taste receptor, leading to the activation of intracellular signaling events such as increased intracellular calcium, which is part of the receptor's functional mechanism for taste signaling. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
An antimalarial drug that has a bitter taste and has been shown to activate bitter taste receptors like T2R16, inducing gustducin activation and subsequent release of calcium from intracellular stores. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
A bitter compound that activates T2R16, resulting in the release of intracellular calcium through the phospholipase C (PLC) pathway, which is instrumental in the taste transduction process. | ||||||
Saccharin | 81-07-2 | sc-212902 sc-212902A sc-212902B | 100 mg 1 g 10 g | $173.00 $235.00 $286.00 | ||
An artificial sweetener that can activate T2R16 at higher concentrations, leading to G-protein activation and subsequent signaling cascades associated with the perception of bitterness. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
A compound known to elicit a bitter taste response, activating T2R16 and its associated G-protein signaling cascades, which can lead to the opening of TRPM5 channels and depolarization of the taste receptor cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
A bitter methylxanthine that is known to activate bitter taste receptors, including T2R16, promoting calcium signaling within the taste cells. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
An inorganic salt with a bitter taste known to activate T2R16, resulting in G-protein signaling and increased intracellular calcium, which are critical for taste transduction. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
A bitter compound that can activate T2R16, leading to the activation of downstream signaling events such as elevated intracellular calcium levels. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
A compound found in mustard oil that has a pungent taste and can activate T2R16, resulting in the enhancement of calcium signaling in taste receptor cells. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
A compound known for its genetic variability in taste perception, which can activate T2R16, leading to the engagement of G-protein coupled signaling pathways and subsequent calcium release. | ||||||