Synaptotagmin XV Activators
Synaptotagmin XV activators belong to a class of compounds that specifically interact with the protein Synaptotagmin XV, a member of the synaptotagmin family of proteins. Synaptotagmins are a group of membrane-trafficking proteins that are known for their role in calcium-dependent exocytosis, particularly in the synaptic vesicle release in neurons. Each synaptotagmin has a characteristic domain structure, including two C2 domains that bind calcium and other molecules, which is crucial for their function. Synaptotagmin XV, like its other family members, plays a role in the intricate process of exocytic membrane fusion, which is essential for the proper functioning of cellular communication pathways.
Activators of Synaptotagmin XV are specialized molecules that can increase the activity or efficiency of Synaptotagmin XV. The exact mechanism by which these activators enhance the protein's function is an area of active research. However, it is known that these activators might interact with the protein's C2 domains or other regulatory regions, thereby potentially altering its calcium-binding properties or its interaction with other proteins and lipids in the cell membrane. By modulating the activity of Synaptotagmin XV, these activators can influence the dynamics of membrane fusion events within cells. This modulation is of particular interest in the context of the precise control of neurotransmitter release, as well as in the general understanding of cellular signaling mechanisms and vesicle trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium ions facilitate the interaction of Synaptotagmin XV with phospholipid membranes, enhancing its role in synaptic vesicle exocytosis. By increasing intracellular calcium concentration, calcium chloride can directly augment Synaptotagmin XV's ability to trigger neurotransmitter release. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate Synaptotagmin XV, thereby increasing its activity in the synaptic vesicle fusion process. PKC-mediated phosphorylation typically enhances Synaptotagmin XV’s role in coupling calcium sensing to vesicle membrane fusion. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates cyclic AMP (cAMP) levels, which activate PKA (protein kinase A). PKA can phosphorylate proteins involved in vesicle trafficking, potentially enhancing Synaptotagmin XV's function in neurotransmitter release by modulating its interaction with the SNARE complex. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DiC8 is a synthetic analog of diacylglycerol (DAG) that activates PKC. This activation can lead to the phosphorylation and subsequent enhancement of Synaptotagmin XV's function in vesicle fusion and neurotransmitter release. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby directly enhancing Synaptotagmin XV’s calcium-dependent triggering of synaptic vesicle exocytosis. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog activates PKA, which can phosphorylate proteins involved in the synaptic vesicle cycle, potentially enhancing the activity of Synaptotagmin XV by promoting its interaction with other vesicle fusion proteins. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that, upon hydrolysis, binds calcium. By buffering intracellular calcium, it can indirectly enhance the specificity of Synaptotagmin XV's calcium sensing during synaptic vesicle release, leading to a more precise neurotransmitter release process. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine modulates the release of calcium from intracellular stores via the ryanodine receptors. This modulation can lead to an increased intracellular calcium concentration that enhances Synaptotagmin XV's calcium-dependent exocytosis of synaptic vesicles. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
Nitrendipine blocks L-type calcium channels, which can fine-tune the calcium influx and thereby enhance the specificity and efficiency of Synaptotagmin XV's role in calcium-triggered vesicle fusion. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644 sensitizes L-type calcium channels, leading to an increase in calcium influx that can potentiate Synaptotagmin XV-mediated vesicle exocytosis by enhancing the calcium signal that triggers this process. | ||||||