Synaptotagmin XIV Activators
Synaptotagmin XIV activators primarily include compounds that interact with associated proteins and pathways to enhance Synaptotagmin XIV activity. A-769662 and Metformin, activators of AMP-activated protein kinase (AMPK), stimulate Synaptotagmin XIV due to its association with the AMPK complex. The activation of AMPK often results in the phosphorylation and subsequent activation of Synaptotagmin XIV, demonstrating the effects of these compounds. Resveratrol, an activator of SIRT1, indicates that SIRT1 activation by Resveratrol can lead to Synaptotagmin XIV activation, as Synaptotagmin XIV acts downstream of SIRT1 in some signaling pathways.
Several inhibitors enhance Synaptotagmin XIV activity by affecting the proteins and pathways that Synaptotagmin XIV negatively regulates. Quercetin, LY294002, and Wortmannin are inhibitors of PI3K. Since Synaptotagmin XIV negatively regulates the PI3K/AKT pathway, inhibiting PI3K enhances Synaptotagmin XIV activity. Similarly, SB203580, an inhibitor of p38 MAPK, can activate Synaptotagmin XIV as it acts downstream of p38 MAPK. The inhibitors of ROCK, Y-27632, and MEK, U0126 and PD98059, also enhance Synaptotagmin XIV activity due to its role in the negative regulation of the Rho/ROCK and MEK/ERK pathways, respectively. Finally, the inhibitors of JNK (SP600125) and mTOR (Rapamycin) enhance Synaptotagmin XIV activity, corroborating with its role in the negative regulation of the JNK and mTOR pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 is an activator of AMP-activated protein kinase (AMPK). Synaptotagmin XIV interacts with the AMPK complex. By activating AMPK, A-769662 can enhance Synaptotagmin XIV activity, as AMPK activation can lead to the phosphorylation and activation of Synaptotagmin XIV. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin is a known activator of AMPK. Similar to A-769662, the activation of AMPK by metformin can enhance Synaptotagmin XIV activity due to the association of Synaptotagmin XIV with the AMPK complex. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural phenol and activator of SIRT1. It has been suggested that Synaptotagmin XIV acts downstream of SIRT1 in certain signaling pathways. Hence, activation of SIRT1 by resveratrol can lead to the activation of Synaptotagmin XIV. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a plant flavonol from the group of polyphenols that inhibits PI3K. Synaptotagmin XIV has been implicated in the negative regulation of the PI3K/AKT pathway. By inhibiting PI3K, quercetin can enhance the activity of Synaptotagmin XIV. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K. Similar to quercetin, by inhibiting PI3K, LY294002 can enhance the activity of Synaptotagmin XIV. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. It has been suggested that Synaptotagmin XIV acts downstream of p38 MAPK in certain signaling pathways. Therefore, inhibition of p38 MAPK can lead to the activation of Synaptotagmin XIV. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK. Synaptotagmin XIV has been implicated in the negative regulation of the Rho/ROCK pathway. Therefore, inhibition of ROCK by Y-27632 can enhance Synaptotagmin XIV activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK. Similar to U0126, by inhibiting MEK, PD98059 can enhance the activity of Synaptotagmin XIV. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. Synaptotagmin XIV has been implicated in the negative regulation of the JNK pathway. Therefore, inhibition of JNK by SP600125 can enhance Synaptotagmin XIV activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR. Synaptotagmin XIV has been implicated in the negative regulation of the mTOR pathway. Therefore, inhibition of mTOR by rapamycin can enhance Synaptotagmin XIV activity. | ||||||