SUV420H2 Activators
SUV420H2 activators can be broadly conceptualized as compounds that influence chromatin remodeling and gene expression, thus indirectly affecting the activity of SUV420H2, a histone methyltransferase. This class of compounds primarily includes inhibitors of DNA methyltransferases and histone deacetylases (HDACs). By altering the methylation and acetylation landscape of chromatin, these compounds can modulate the availability of histone substrates for SUV420H2 or alter the chromatin context in which SUV420H2 operates, thereby influencing its activity.
The chemical structures and properties of these compounds vary, encompassing nucleoside analogs like 5-Azacytidine, hydroxamic acids such as Trichostatin A and Vorinostat, and short-chain fatty acids like Valproic Acid. Each of these chemicals interacts with distinct molecular targets but converges in their overall effect on chromatin dynamics. For instance, DNA methyltransferase inhibitors like 5-Azacytidine and RG108 reduce DNA methylation levels, leading to a more open chromatin state, which could facilitate SUV420H2-mediated methylation. On the other hand, HDAC inhibitors, including Trichostatin A, Vorinostat, and Valproic Acid, increase histone acetylation, another modification known to influence chromatin structure and gene expression.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor. By inhibiting DNA methylation, it can lead to changes in chromatin structure, potentially affecting SUV420H2's role in histone methylation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor. It alters acetylation patterns on histones, which could indirectly influence SUV420H2's histone methylation activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, similar in function to Trichostatin A, potentially affecting SUV420H2 activity by altering histone acetylation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A short-chain fatty acid and a histone deacetylase inhibitor. It can influence chromatin remodeling, potentially affecting SUV420H2's activity. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
An inhibitor of G9a and GLP histone lysine methyltransferases. By altering methylation patterns, it may indirectly influence SUV420H2 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A DNA methyltransferase inhibitor. It can change DNA methylation patterns, potentially influencing SUV420H2's histone methylation function. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
A histone deacetylase inhibitor. By altering histone acetylation, it may indirectly affect SUV420H2 activity. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
A histone deacetylase inhibitor. It can modify chromatin structure and potentially influence SUV420H2 activity. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
A potent histone deacetylase inhibitor. Its action on histone acetylation could indirectly affect SUV420H2. | ||||||
PI3K/HDAC Inhibitor | 1339928-25-4 | sc-364584 sc-364584A | 5 mg 10 mg | $347.00 $471.00 | ||
A dual PI3K and histone deacetylase inhibitor. It could indirectly influence SUV420H2 by altering multiple pathways involved in chromatin remodeling. | ||||||