SUT-1 Inhibitors
SUT-1 inhibitors, or Sodium-dependent glucose transporter 1 inhibitors, belong to a distinct chemical class of compounds that are specifically designed to target and modulate the activity of the SUT-1 protein. SUT-1, also known as SLC5A1, is a membrane protein primarily found in the intestinal epithelial cells and is responsible for the active transport of glucose molecules from the intestinal lumen into the bloodstream. This transporter plays a crucial role in the absorption of dietary glucose, which is essential for providing energy to the body. SUT-1 inhibitors are designed to interfere with the function of this transporter, ultimately inhibiting the uptake of glucose across the intestinal epithelium.
Chemically, SUT-1 inhibitors can encompass a diverse range of compounds with varying structures and mechanisms of action. These inhibitors typically interact with SUT-1 through reversible or irreversible binding, thereby disrupting its ability to transport glucose effectively. Some SUT-1 inhibitors may compete with glucose for binding sites on the transporter, while others may alter the conformation of SUT-1, rendering it non-functional. Research in this field has led to the identification of several promising lead compounds and the development of structural analogs with improved potency and selectivity
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT-1 by binding to its allosteric site. This activation leads to increased deacetylation of histones and other protein substrates, promoting longevity and metabolic health. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SRT1720 is a selective SIRT-1 activator that enhances SIRT-1's deacetylase activity, promoting mitochondrial biogenesis and improved metabolism. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
EX-527 is a potent SIRT-1 inhibitor that competitively binds to its catalytic site, reducing deacetylase activity. It's used to study SIRT-1 function in aging and disease. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $145.00 | 4 | |
Cambinol is a SIRT-1 inhibitor that blocks the enzyme's deacetylase activity by binding to its catalytic site, regulating various cellular processes and gene expression. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 inhibits SIRT-1 by destabilizing the enzyme's protein structure, leading to its degradation and reducing its deacetylase activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide competes with NAD+ for binding to SIRT-1, inhibiting its deacetylase activity. It's a natural precursor of NAD+ and plays a role in cellular metabolism. | ||||||
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $48.00 | ||
Splitomicin inhibits SIRT-1 by blocking its access to NAD+, a cofactor essential for its deacetylase activity. It's a research tool for studying SIRT-1 function. | ||||||
SIRT2 Inhibitor, AGK2 | 304896-28-4 | sc-202813A sc-202813 sc-202813B sc-202813C | 1 mg 5 mg 10 mg 25 mg | $46.00 $148.00 $316.00 $490.00 | 5 | |
AGK2 is a SIRT-1 inhibitor that binds to its catalytic site, inhibiting deacetylase activity. It's used in research to study SIRT-1's role in various biological processes. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin inhibits SIRT-1 by binding to its catalytic domain. This inhibition can affect various pathways and has potential therapeutic applications. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a class I and II HDAC inhibitor, indirectly affecting SIRT-1. It promotes histone acetylation, influencing gene expression and cell growth regulation. | ||||||