SUMO-2 Activators
Common SUMO-2 Activators include, but are not limited to Arsenic(III) oxide CAS 1327-53-3, Trichostatin A CAS 58880-19-6, Resveratrol CAS 501-36-0, Genistein CAS 446-72-0 and Etoposide (VP-16) CAS 33419-42-0.
SUMO-2, which stands for Small Ubiquitin-like Modifier 2, activators are compounds or molecules that stimulate the conjugation and function of SUMO-2 within cells. SUMO-2 is part of a family of proteins that play a crucial role in post-translational modification, specifically in a process known as SUMOylation. SUMOylation involves the covalent attachment of SUMO proteins to target proteins, which can alter their function, stability, localization, and interactions with other molecules. SUMO-2 is one of several SUMO paralogs in humans, including SUMO-1 and SUMO-3, each with distinct functions.
SUMOylation is essential for a wide range of cellular processes, including DNA repair, transcriptional regulation, protein stability, and cellular localization. SUMO-2 activators enhance this SUMOylation process, which can, in turn, impact the function of numerous target proteins. This regulation plays a pivotal role in maintaining cellular homeostasis and responding to various cellular stresses. The specificity and selectivity of SUMOylation are tightly controlled by the enzymatic machinery responsible for SUMO conjugation and deconjugation. SUMO-2 activators are essential tools in research aimed at understanding the intricate regulatory networks governed by SUMOylation and how they influence cell biology, which has implications for various fields, including cancer research, neurobiology, and cellular stress responses. These activators are invaluable in deciphering the roles of SUMO-2 in health and disease, shedding light on the complex mechanisms that underlie cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
DNA damaging agent that activates the DDR pathway involving ATM/ATR kinases and upregulation of SUMO-2 transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor that opens chromatin structure at SUMO-2 promoter allowing greater transcription factor binding. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates SIRT1 which can desuccinylate and activate transcription factors that bind the SUMO-2 promoter. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
HDAC inhibitor that enhances histone acetylation states permitting improved SUMO-2 transcriptional regulation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
DNA topoisomerase inhibitor causing DSBs and activating DDR signaling leading to ATF3 binding SUMO-2 promoter. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Metal toxin triggering DDR through ATM and Egr-1 transactivation of the SUMO-2 promoter. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
DNA intercalating agent which activates p53/ETS2 regulation of SUMO-2 promoter in response to DNA damage. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Mdm2 inhibitor stabilizing and activating p53 to enhance SUMO-2 transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
PKA activator which regulates SUMO-2 transcription factor phosphorylation controlling its activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Antioxidant that may increase SUMO-2 expression by alleviating oxidative inhibition of transcription factors. | ||||||