SULT2A2 Activators
SULT2A2 activators are primarily indirect agents that facilitate the enzyme's activity by modulating its expression or the biochemical conditions necessary for its function. These compounds interact with various cellular pathways to ensure the enzyme has the requisite cofactors or substrates, or to stimulate the transcription of the gene encoding SULT2A2. ATP, for instance, is crucial for the generation of PAPS, the donor molecule required for the sulfonation reaction catalyzed by SULT2A2. Adequate levels of ATP can, therefore, underpin the enzyme's activity by maintaining a supply of this cofactor.
On a genomic level, compounds like phenobarbital and rifampicin can induce the expression of liver enzymes including SULT2A2 by activating nuclear receptors that enhance the transcription of detoxification-related genes. Similarly, dexamethasone and retinoic acid can also modulate gene expression through their respective receptor-mediated pathways. In contrast, 5-azacytidine can demethylate DNA, potentially leading to the upregulation of SULT2A2 expression.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
As a precursor for PAPS synthesis, ATP can indirectly support SULT2A2 activity by ensuring the availability of the required cofactor. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium is a cofactor for many enzymes, including those involved in the synthesis of PAPS, thereby supporting SULT2A2 function. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
A flavonoid that can modulate various enzyme activities and might influence SULT2A2 indirectly via alterations in hepatic metabolism. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A glucocorticoid that can induce the expression of some hepatic enzymes, possibly including SULT2A2, through glucocorticoid receptor-mediated pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A that regulates gene expression, potentially including genes encoding sulfotransferases like SULT2A2. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
An antibiotic known to induce liver enzyme expression, which could potentially include SULT2A2 via pregnane X receptor (PXR) activation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can alter gene expression, possibly upregulating SULT2A2. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
A compound in cruciferous vegetables that can induce the expression of detoxification enzymes, possibly including SULT2A2. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
A thyroid hormone that can modulate liver enzyme expression, which may influence SULT2A2 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels which can lead to the transcriptional regulation of various enzymes, potentially including SULT2A2. | ||||||