SUHW4 Inhibitors
SUHW4 inhibitors constitute a class of chemical compounds that interact with a specific molecular target, known as SUHW4, which is a part of a larger family of proteins with distinct biological functions. These proteins often play a role in the regulation of gene expression by interacting with DNA in a specific manner. The inhibitors are designed to bind to the SUHW4 protein, thereby impacting its natural function. The design and development of these inhibitors involve a meticulous understanding of the protein's structure, the nature of its active site, and the dynamics of its interaction with DNA or other relevant molecules. SUHW4 inhibitors are typically small molecules that can enter cells and reach the SUHW4 protein, engaging with it in a way that alters its activity.
The development of SUHW4 inhibitors involves a combination of medicinal chemistry, biochemistry, and molecular biology techniques. Researchers utilize structure-activity relationships (SAR) to understand how different chemical substitutions on the inhibitor can affect its binding affinity and specificity towards the SUHW4 protein. This is frequently done using computational models that predict how a molecule will interact with the protein, followed by the synthesis and testing of the molecule in biochemical assays. The biochemical assays are designed to measure the degree to which these inhibitors can affect the function of SUHW4. Critical to this process is the ability to measure interactions with high sensitivity and specificity, often necessitating the use of advanced analytical techniques such as mass spectrometry, fluorescence-based assays, or surface plasmon resonance. These methods help in characterizing the binding kinetics and thermodynamics of the inhibitor-protein interaction, which are crucial for the iterative process of optimizing the inhibitor's chemical structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that increases acetylation of histones, leading to changes in chromatin structure and gene expression. SUHW4, as a transcription factor, may have its DNA binding affinity and activity reduced when chromatin structure is more open due to increased histone acetylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling is critical for many aspects of cell growth and survival. Inhibition of PI3K can lead to reduced transcriptional activity of various proteins, potentially including SUHW4, by altering cellular survival and growth pathways. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that leads to hypomethylation of DNA. This can affect the expression of certain genes and indirectly impact the activity of transcription factors such as SUHW4 by changing the epigenetic landscape. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that interferes with the MAPK/ERK pathway. This pathway can regulate the activity of various transcription factors and thus may indirectly affect SUHW4 by altering the phosphorylation status of proteins that interact with or regulate SUHW4. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor that blocks translational elongation. By inhibiting general protein synthesis, it can indirectly decrease the functional activity of SUHW4 by preventing the synthesis of proteins that may stabilize or enhance SUHW4's activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can suppress cell growth and proliferation. As mTOR is involved in the regulation of protein synthesis and other cellular processes, its inhibition could indirectly lead to reduced activity of transcription factors such as SUHW4 by affecting overall protein homeostasis. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can disrupt cell cycle progression. By inhibiting CDKs, the chemical could potentially alter the phosphorylation state of proteins that regulate SUHW4, thus affecting its activity indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor which can affect inflammatory response and differentiation pathways. Inhibition of p38 MAPK could lead to changes in transcription factor dynamics, potentially affecting SUHW4 activity through altered signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor which can impact apoptosis and cellular stress responses. By inhibiting JNK, it might influence the activity of transcription factors including SUHW4, through changes in cellular response to stress and apoptosis signals. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Accumulation of such proteins could indirectly influence SUHW4 by altering the degradation rates of proteins that modulate SUHW4 activity. | ||||||