STS-1 Inhibitors
Chemical inhibitors of STS-1 can be understood through their action on various signaling pathways that are integral to the activation and function of this protein. Dasatinib, PP2, SU6656, and Go6976 are inhibitors of the Src family kinases such as Lck and Fyn, which are crucial in the initiation of T-cell receptor (TCR) signaling. By inhibiting these kinases, the activation of downstream molecules in the TCR pathway, including STS-1, is prevented. This results in the functional inhibition of STS-1 as it cannot be activated without the upstream signals provided by the Src family kinases. Similarly, PP1, another Src family kinase inhibitor, disrupts the signaling cascade leading to the activation of STS-1, thereby inhibiting its function.
Wortmannin and LY294002 specifically target PI3K, a kinase that participates in various signaling pathways, including those involving STS-1. Inhibition of PI3K by these chemicals leads to a disruption in the signaling pathways, preventing the functional activation of STS-1. PIK-75, which is more selective for the p110α isoform of PI3K, similarly disrupts the signal transduction processes that would lead to STS-1 activation. U0126 and PD98059, which are inhibitors of MEK, an upstream kinase in the MAPK/ERK pathway, prevent the activation of this pathway, thereby indirectly inhibiting the function of STS-1 which operates downstream. SB203580, a p38 MAPK inhibitor, and SP600125, a JNK inhibitor, also impede the activation of STS-1 by inhibiting the respective kinases involved in their pathways.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor that can inhibit the T-cell receptor (TCR) signaling. Since STS-1 is known to be a negative regulator of TCR signaling, dasatinib's inhibition of Lck and Fyn kinases, which are upstream of STS-1 in the TCR pathway, would result in the functional inhibition of STS-1 by preventing its activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor that targets Lck and Fyn, which are pivotal in TCR signaling. The inhibition of these kinases by PP2 leads to the suppression of the TCR signaling cascade, thereby inhibiting the activity of STS-1, which functions downstream of these kinases. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $57.00 $133.00 | 27 | |
SU6656 is another Src family kinase inhibitor that impairs the activation of kinases such as Lck and Fyn. By doing so, SU6656 prevents the downstream TCR signaling that would normally involve STS-1, effectively inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. PI3K is a key signaling molecule in multiple pathways, including those that involve STS-1. By inhibiting PI3K, wortmannin can suppress the signaling pathways that lead to the activation of STS-1, hence inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor, which by the same mechanism as wortmannin, leads to the inhibition of downstream signaling pathways. This results in the functional inhibition of STS-1, which is part of those pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor; it inhibits the MAPK/ERK pathway, which is involved in T-cell activation. Since STS-1 functions downstream in this pathway, U0126 can inhibit the activation of STS-1 by inhibiting the upstream kinases. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 selectively inhibits MEK, which is upstream of the MAPK/ERK pathway. By inhibiting MEK, PD98059 indirectly inhibits the activation of STS-1, which operates within this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it can disrupt the signaling pathway that involves STS-1, leading to the functional inhibition of STS-1 by preventing its activation through this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. The inhibition of JNK leads to the disruption of signaling pathways that activate STS-1. This results in the functional inhibition of STS-1's activity as it is part of the JNK signaling pathway. | ||||||
PP 1 | 172889-26-8 | sc-203212 sc-203212A | 1 mg 5 mg | $86.00 $145.00 | 6 | |
PP1 is a potent and selective inhibitor of Src family kinases including Lck and Fyn, which are involved in TCR signaling. Inhibition of these kinases by PP1 leads to decreased activation of downstream signaling molecules like STS-1. | ||||||