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STS-1 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects STS-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-STS-1 antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STS-1, also known as UBASH3B or p70, plays a crucial role in negatively regulating signaling pathways downstream of the T cell receptor, which is vital for maintaining immune system balance and preventing overactivation of T cells. STS-1 is primarily localized in the cytoplasm and nucleus, with expression levels varying across different tissues; notably, STS-1 is minimally expressed in the pancreas, ovary, and heart. Structurally, STS-1 features an N-terminal ubiquitin-associated domain, a single SH3 domain, and a C-terminal domain that resembles the catalytic domain of phosphoglycerate mutases, which contributes to phosphatase activity. STS-1 interacts with activated epidermal growth factor receptor complexes, inhibiting their endocytosis and thereby regulating receptor internalization and cellular responses to growth factors. This regulatory function underscores STS-1 ′s significance in controlling receptor tyrosine kinase endocytosis and broader implications in cellular signaling and immune response modulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UBASH3B/STS1 Antibody (E-8) | sc-514612 | 200 µg/ml | $316.00 | |||
UBASH3B/STS1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-531176 | 200 µg Ab; 10 µg BP | $354.00 | |||
UBASH3B/STS1 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-524790 | 200 µg Ab, 40 µg BP | $354.00 | |||
UBASH3B/STS1 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-544424 | 200 µg Ab; 20 µg BP | $354.00 | |||
UBASH3B/STS1 Antibody (E-8) AC | sc-514612 AC | 500 µg/ml, 25% agarose | $416.00 | |||
UBASH3B/STS1 Antibody (E-8) HRP | sc-514612 HRP | 200 µg/ml | $316.00 | |||
UBASH3B/STS1 Antibody (E-8) FITC | sc-514612 FITC | 200 µg/ml | $330.00 | |||
UBASH3B/STS1 Antibody (E-8) PE | sc-514612 PE | 200 µg/ml | $343.00 | |||
UBASH3B/STS1 Antibody (E-8) Alexa Fluor® 488 | sc-514612 AF488 | 200 µg/ml | $357.00 | |||
UBASH3B/STS1 Antibody (E-8) Alexa Fluor® 546 | sc-514612 AF546 | 200 µg/ml | $357.00 | |||
UBASH3B/STS1 Antibody (E-8) Alexa Fluor® 594 | sc-514612 AF594 | 200 µg/ml | $357.00 | |||
UBASH3B/STS1 Antibody (E-8) Alexa Fluor® 647 | sc-514612 AF647 | 200 µg/ml | $357.00 | |||
UBASH3B/STS1 Antibody (E-8) Alexa Fluor® 680 | sc-514612 AF680 | 200 µg/ml | $357.00 | |||
UBASH3B/STS1 Antibody (E-8) Alexa Fluor® 790 | sc-514612 AF790 | 200 µg/ml | $357.00 |