Stra13 Activators
Retinoic acid, by engaging with nuclear receptors, and Cholecalciferol, through its hormonal action, both foster gene transcription, with Stra13 being among the genes that can be expressed as a result. Butyrate and its sodium salt, alongside Trichostatin A and sulforaphane, act as histone deacetylase inhibitors, relaxing the chromatin structure to promote gene expression, thereby setting the stage for increased transcription of Stra13. Forskolin serves to amplify the levels of cAMP, a secondary messenger that activates CREB, a transcription factor that may enhance the transcription of Stra13. The demethylating agent 5-Aza-2'-deoxycytidine removes epigenetic silencing marks from DNA, which can lead to the reactivation of otherwise silent genes, including Stra13. Phorbol esters like PMA engage protein kinase C, igniting a signaling cascade that culminates in the activation of transcription factors and the potential transcriptional activation of Stra13.
Lithium chloride impedes the action of glycogen synthase kinase 3, an inhibition that stabilizes and activates certain transcription factors, possibly increasing Stra13 expression. Resveratrol, by activating sirtuin 1, modifies the acetylation status of histones and non-histone proteins, influencing gene expression patterns in favor of Stra13's activation. Epigallocatechin gallate, alters gene expression by affecting epigenetic modifications, which may result in Stra13's upregulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A (retinol), activates the retinoid receptors which can lead to the upregulation of Stra13 expression as it does with certain other retinoic acid-responsive genes. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyrate, a short-chain fatty acid, acts as a histone deacetylase inhibitor, leading to chromatin remodeling and can increase the transcription of certain genes, including possibly Stra13. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is also a histone deacetylase inhibitor that promotes acetylation of histones, facilitating transcriptional activation of multiple genes, which can include Stra13. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, by activating adenylyl cyclase, increases cAMP levels and can activate the cAMP response element-binding protein (CREB), which may enhance the transcription of genes under CREB regulation, such as Stra13. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound, a DNA methyltransferase inhibitor, can cause demethylation of DNA, potentially leading to the activation of gene expression, including genes like Stra13. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 through its active form can engage vitamin D receptors which can influence the expression of numerous genes, including potentially Stra13. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which is involved in various signaling pathways and can lead to the activation of transcription factors that enhance gene expression, including potentially Stra13. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate sirtuin 1 (SIRT1), which is involved in the deacetylation of histones and non-histone proteins and may lead to the upregulation of several genes including Stra13. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3) leading to the stabilization and activation of transcription factors, thereby potentially increasing the expression of target genes like Stra13. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Similar to butyrate, sodium butyrate acts as a histone deacetylase inhibitor, potentially enhancing the expression of several genes, including Stra13. | ||||||