STPG2 Activators
STPG2 activators mainly include compounds that interact with associated proteins and pathways to enhance STPG2 activity. A-769662 and Metformin, activators of AMP-activated protein kinase (AMPK), stimulate STPG2 due to its association with the AMPK complex. The activation of AMPK often results in the phosphorylation and subsequent activation of STPG2, demonstrating the effects of these compounds. Resveratrol, an activator of SIRT1, indicates that SIRT1 activation by Resveratrol can lead to STPG2 activation, as STPG2 acts downstream of SIRT1 in some signaling pathways.
Several inhibitors enhance STPG2 activity by affecting the proteins and pathways that STPG2 negatively regulates. Quercetin, LY294002, and Wortmannin are inhibitors of PI3K. Since STPG2 negatively regulates the PI3K/AKT pathway, these inhibitors enhance STPG2 activity. The p38 MAPK inhibitor SB203580 can activate STPG2, which acts downstream of p38 MAPK in some signaling pathways. Y-27632, a ROCK inhibitor, and U0126 and PD98059, MEK inhibitors, can enhance STPG2 activity by inhibiting the Rho/ROCK andMEK/ERK pathways, respectively, which STPG2 negatively regulates. Similarly, the JNK inhibitor SP600125 and the mTOR inhibitor Rapamycin can enhance STPG2 activity by inhibiting the JNK and mTOR pathways, respectively. Each of these compounds has a specific effect on the signaling pathways that STPG2 is involved in, leading to enhanced functional activity of STPG2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662 is an activator of AMP-activated protein kinase (AMPK). STPG2 has been found to associate with the AMPK complex. By activating AMPK, A-769662 can enhance STPG2 activity, as AMPK activation can lead to the phosphorylation and activation of STPG2. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is a known activator of AMPK. Similar to A-769662, the activation of AMPK by metformin can enhance STPG2 activity due to the association of STPG2 with the AMPK complex. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol and activator of SIRT1. It has been suggested that STPG2 acts downstream of SIRT1 in certain signaling pathways. Hence, activation of SIRT1 by resveratrol can lead to the activation of STPG2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a plant flavonol from the group of polyphenols that inhibits PI3K. STPG2 has been implicated in the negative regulation of the PI3K/AKT pathway. By inhibiting PI3K, quercetin can enhance the activity of STPG2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K. Similar to quercetin, by inhibiting PI3K, LY294002 can enhance the activity of STPG2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. It has been suggested that STPG2 acts downstream of p38 MAPK in certain signaling pathways. Therefore, inhibition of p38 MAPK can lead to the activation of STPG2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK. STPG2 has been implicated in the negative regulation of the Rho/ROCK pathway. Therefore, inhibition of ROCK by Y-27632 can enhance STPG2 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK. Similar to U0126, by inhibiting MEK, PD98059 can enhance the activity of STPG2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. STPG2 has been implicated in the negative regulation of the JNK pathway. Therefore, inhibition of JNK by SP600125 can enhance STPG2 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR. STPG2 has been implicated in the negative regulation of the mTOR pathway. Therefore, inhibition of mTOR by rapamycin can enhance STPG2 activity. | ||||||