Staf-50 Activators
Staf-50 activators primarily function through pathways that modulate gene expression via epigenetic modifications or alter protein function via post-translational modifications. Compounds such as Epigallocatechin gallate, 5-Azacytidine, Zebularine, and RG108 work by inhibiting DNA methyltransferases (DNMTs). DNMTs suppress the expression of Staf-50 by adding a methyl group to the DNA at the gene locus, which generally reduces gene transcription. When the activity of these enzymes is inhibited, the methylation of DNA is reduced, leading to enhanced transcription of Staf-50 and hence an increase in its functional activity.
On the other hand, chemicals likeGenistein, Quercetin, and Dasatinib enhance Staf-50 functionality by inhibiting protein tyrosine kinases (PTKs). PTKs are known to phosphorylate and inactivate Staf-50, and their inhibition leads to increased protein activity. Similarly, Histone deacetylases (HDACs) are another class of enzymes targeted by Staf-50 activators. Compounds like Trichostatin A, Vorinostat (Suberoylanilide Hydroxamic Acid), Sodium butyrate, and Phenethyl isothiocyanate inhibit HDACs, preventing them from removing acetyl groups from histones, an action that typically suppresses gene expression. This inhibition leads to enhanced Staf-50 expression. Lastly, Pyridostatin enhances the function of Staf-50 by stabilizing G-quadruplexes in the Staf-50 promoter region, facilitating its transcription.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol present in green tea. EGCG is a known inhibitor of DNA methyltransferases (DNMTs). Since DNMTs can suppress Staf-50 expression by DNA methylation, inhibition of DNMTs by EGCG can lead to enhanced functional activity of Staf-50. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNMT inhibitor. It incorporates itself into DNA and traps DNMTs, preventing DNA methylation. This can lead to the enhanced functional activity of Staf-50 through the prevention of its suppression via DNA methylation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soy products. It is a known inhibitor of protein tyrosine kinases (PTKs). Since PTKs can inactivate Staf-50 by phosphorylation, inhibition of PTKs by Genistein can lead to enhanced functional activity of Staf-50. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has antioxidant properties. It is known to inhibit PTKs. Since PTKs can inactivate Staf-50 by phosphorylation, inhibition of PTKs by Quercetin can lead to enhanced functional activity of Staf-50. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a potent inhibitor of multiple tyrosine kinases. By inhibiting these kinases, Dasatinib can prevent the phosphorylation and inactivation of Staf-50, leading to its enhanced functional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases (HDACs). Since HDACs can suppress Staf-50 expression by histone deacetylation, inhibition of HDACs by Trichostatin A can lead to enhanced functional activity of Staf-50. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is an inhibitor of HDACs. As HDACs can suppress Staf-50 expression by histone deacetylation, inhibition of HDACs by Vorinostat can lead to enhanced functional activity of Staf-50. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a cytidine analog that acts as a DNMT inhibitor. It incorporates into DNA and traps DNMTs, preventing DNA methylation. This can lead to enhanced functional activity of Staf-50 by preventing its suppression via DNA methylation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as an inhibitor of HDACs. This can lead to enhanced functional activity of Staf-50 by preventing its suppression via histone deacetylation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a non-nucleoside inhibitor of DNMTs. It prevents DNMTs from accessing DNA, thereby preventing DNA methylation. This can lead to enhanced functional activity of Staf-50. | ||||||