SSXB2 Activators
Chemical activators of SSXB2 can initiate a variety of signaling pathways within cells, often through the phosphorylation of this protein, which modulates its activity. Phorbol 12-myristate 13-acetate, for example, can activate Protein Kinase C (PKC), a key player in many signaling cascades. PKC, once activated, can phosphorylate SSXB2, thereby altering its function within the cell. Similarly, Forskolin can raise intracellular cAMP levels, leading to the activation of Protein Kinase A (PKA), another kinase able to phosphorylate SSXB2. This activation pathway is further supported by compounds like 3-Isobutyl-1-methylxanthine and Dibutyryl cAMP, which prevent the breakdown of cAMP or act as a cAMP analog, respectively, thus enhancing PKA activity and subsequent phosphorylation of SSXB2.
Calcium signaling also plays a crucial role in the regulation of SSXB2. Ionomycin can increase intracellular calcium concentrations, which may activate calcium-dependent kinases that phosphorylate SSXB2. Thapsigargin operates in a similar manner, inducing the release of calcium from intracellular stores and activating calcium-dependent kinases that can phosphorylate SSXB2. Furthermore, various inhibitors like Okadaic Acid, Sodium orthovanadate, and Calyculin A can prevent the dephosphorylation of SSXB2. By inhibiting protein phosphatases, these compounds maintain SSXB2 in a phosphorylated and active state. In addition, Anisomycin activates stress-activated protein kinases, which can target and phosphorylate SSXB2. The Epidermal Growth Factor (EGF) stimulates its receptor to initiate a cascade involving multiple kinases that can also lead to the phosphorylation of SSXB2, integrating it into growth factor signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
This compound activates Protein Kinase C (PKC), which in turn can phosphorylate and activate SSXB2 as part of signal transduction pathways that SSXB2 is involved in. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentrations, which can activate calcium-dependent kinases that phosphorylate and activate SSXB2 in calcium signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
By inducing the release of intracellular calcium stores, Thapsigargin activates calcium-dependent kinases that are capable of phosphorylating SSXB2, resulting in its activation within calcium-mediated signaling processes. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a protein phosphatase inhibitor that prevents dephosphorylation of proteins. It can maintain SSXB2 in a phosphorylated and hence active state by inhibiting the phosphatases that would otherwise deactivate SSXB2. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases which can phosphorylate SSXB2, leading to its activation in response to cellular stress signals. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
This phosphodiesterase inhibitor prevents cAMP breakdown, thereby activating PKA, which can then phosphorylate and activate SSXB2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
As a cAMP analog, Dibutyryl cAMP can directly activate PKA which can phosphorylate and activate SSXB2 in cAMP-dependent signaling pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
This inhibitor of tyrosine phosphatases prevents dephosphorylation of proteins. It can maintain SSXB2 in an active state by inhibiting the phosphatases that would otherwise deactivate it. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, similar to Okadaic Acid, is a potent inhibitor of protein phosphatases 1 and 2A, which can result in the sustained phosphorylation and activation of SSXB2 by preventing its dephosphorylation. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
Although not an activator, 4α-Phorbol serves as a biologically inactive analog to PMA and can be used to confirm the specificity of PKC-mediated activation of SSXB2 in experiments, by demonstrating lack of activation when SSXB2 is treated with this compound. | ||||||