Date published: 2026-5-16

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SSEA-4 Activators

SSEA-4 Activators belong to a unique class of chemical compounds that are primarily recognized for their ability to modulate specific cellular processes involving a glycolipid called SSEA-4 (Stage-specific Embryonic Antigen-4). SSEA-4 is a cell surface marker found on the surface of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs). These cells are crucial for various developmental and regenerative processes in the human body. SSEA-4 Activators, as the name suggests, are compounds that can influence the behavior and properties of cells expressing SSEA-4, particularly in the context of stem cell biology and developmental research.

SSEA-4 Activators work by interacting with the SSEA-4 glycolipid or its associated signaling pathways within the cell. This interaction can lead to various outcomes, such as the promotion of self-renewal and pluripotency in stem cells or the enhancement of differentiation into specific cell lineages. Researchers often utilize SSEA-4 Activators in laboratory settings to explore the fundamental mechanisms underlying stem cell biology and differentiation processes. By manipulating SSEA-4 expression or activity, scientists can gain insights into the intricate regulatory networks governing cellular fate determination during development. These compounds are invaluable tools for advancing our understanding of early embryonic development, tissue regeneration, and disease modeling, shedding light on the intricacies of cellular fate decisions and opening up new avenues for scientific exploration.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid is a derivative of vitamin A and is commonly used in cell culture to induce differentiation and SSEA-4 expression in human embryonic stem cells.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

Valproic acid is a histone deacetylase (HDAC) inhibitor that can enhance SSEA-4 expression and is employed in reprogramming human cells into a pluripotent state.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

SB431542 is a selective inhibitor of the TGF-β receptor and helps maintain pluripotency and SSEA-4 expression in human embryonic stem cells.

GSK-3 Inhibitor XVI

252917-06-9sc-221691
sc-221691A
5 mg
25 mg
$180.00
$610.00
4
(1)

CHIR99021 is a glycogen synthase kinase 3 (GSK-3) inhibitor that supports self-renewal and SSEA-4 expression in human embryonic stem cells.

ALK5 Inhibitor II

446859-33-2sc-221234
sc-221234A
sc-221234B
sc-221234C
sc-221234D
sc-221234E
sc-221234F
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$77.00
$153.00
$219.00
$663.00
$1248.00
$4382.00
$7850.00
8
(1)

RepSox is a small molecule inhibitor of the TGF-β receptor that can help maintain pluripotency and SSEA-4 expression in stem cells.

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$202.00
$811.00
16
(1)

A83-01 is an inhibitor of TGF-β signaling and enhances SSEA-4 expression in human embryonic stem cells while maintaining their undifferentiated state.

Thiazovivin

1226056-71-8sc-361380
sc-361380A
10 mg
25 mg
$284.00
$634.00
15
(1)

Thiazovivin is a Rho-associated protein kinase (ROCK) inhibitor that supports the survival and SSEA-4 expression of human embryonic stem cells in single-cell culture.

SU 5402

215543-92-3sc-204308
sc-204308A
1 mg
5 mg
$63.00
$98.00
36
(3)

SU5402 is a fibroblast growth factor receptor (FGFR) inhibitor that helps regulate SSEA-4 expression and differentiation in stem cells.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

Y-27632 is a ROCK inhibitor that promotes cell survival and SSEA-4 expression during the culture and passaging of human embryonic stem cells.