SSBP2 Activators
SSBP2 activators primarily employ a mechanism of action that involves the modulation of the PI3K/AKT signaling pathway. This modulation is achieved by the inhibition of key enzymes in the pathway, such as PI3K, AKT, mTOR, and protein tyrosine kinases. Activators such as Genistein, LY294002, Wortmannin, Rapamycin, Quercetin, Triciribine, Resveratrol, BEZ235, Perifosine, SF1126, A66, and GDC-0941 work by inhibiting these enzymes. This strategic inhibition leads to the activation of the PI3K/AKT pathway, which is known to be involved in the functional activity of SSBP2. The overall effect produced by these chemicals is an upregulation of the PI3K/AKT signaling pathway, thereby enhancing the functional activity of SSBP2. The increased activity in this pathway can result in the activation of SSBP2 and the subsequent downstream effects. The chemicals mentioned above, in their respective ways, all contribute to this overall upregulation of the pathway. Through their individual mechanisms of inhibiting key enzymes, they all play a rolein the activation of the PI3K/AKT signaling pathway, and hence, the functional enhancement of SSBP2.
Inhibition of the aforementioned enzymes essentially acts as a molecular switch, turning up the activity of the PI3K/AKT pathway. As SSBP2 is implicated in this pathway, these activators are crucial in influencing its functional activity. The specific mechanism of each of these chemicals, whether it be through the inhibition of PI3K, mTOR, AKT, or protein tyrosine kinases, results in an enhanced activation of SSBP2. This is achieved by the indirect effect these chemicals have on the PI3K/AKT signaling pathway, a known modulator of SSBP2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can upregulate the PI3K/AKT signalling pathway. SSBP2 has been implicated in the PI3K/AKT signalling pathway, and thus, genistein's ability to upregulate the pathway can enhance the functional activity of SSBP2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Inhibition of PI3Ks can lead to the activation of the PI3K/AKT pathway, thereby enhancing the functional activity of SSBP2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, it can lead to the activation of the PI3K/AKT pathway which can indirectly enhance the functional activity of SSBP2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a mTOR inhibitor. By inhibiting mTOR, it can lead to the upregulation of the PI3K/AKT pathway which can enhance the functional activity of SSBP2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit protein tyrosine kinase. This inhibition can lead to the activation of the PI3K/AKT pathway, enhancing the functional activity of SSBP2. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is a selective inhibitor of AKT. By inhibiting AKT, it can lead to the activation of the PI3K/AKT pathway which can indirectly enhance the functional activity of SSBP2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural polyphenol that is known to activate sirtuins. This activation can indirectly lead to upregulation of the PI3K/AKT pathway, enhancing the functional activity of SSBP2. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
BEZ235 is a dual PI3K/mTOR inhibitor. By inhibiting these enzymes, it can lead to the activation of the PI3K/AKT pathway, thereby enhancing the functional activity of SSBP2. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an AKT inhibitor. By inhibiting AKT, it can lead to the activation of the PI3K/AKT pathway which can indirectly enhance the functional activity of SSBP2. | ||||||
SF1126 | 936487-67-1 | sc-391584 sc-391584A | 5 mg 10 mg | $719.00 $1331.00 | 7 | |
SF1126 is a pan-PI3K inhibitor. By inhibiting PI3K, it can lead to the activation of the PI3K/AKT pathway which can indirectly enhance the functional activity of SSBP2. | ||||||