SSB-3 Activators
Forskolin engages the adenylate cyclase enzyme with precision, resulting in an upsurge of cyclic AMP (cAMP), a secondary messenger pivotal in the activation of protein kinase A (PKA). This activation sequence sets the stage for phosphorylation, a post-translational modification essential in the regulation of protein activity. IBMX complements this process by its inhibitory action on phosphodiesterases, enzymes responsible for cAMP degradation, thus augmenting and prolonging the signal initiated by Forskolin.
Genistein's subtle engagement with tyrosine kinases alters phosphorylation landscapes, potentially leading to the activation of a variety of proteins, including those unrelated to its primary inhibitory role. Phorbol esters like PMA specifically activate protein kinase C (PKC), which phosphorylates target proteins, while calcium mobilizers like Ionomycin and Thapsigargin, along with the ionophore A23187, harness the universal second messenger calcium to initiate protein activation through calmodulin-dependent kinases. LY294002 and U0126 selectively inhibit PI3K and MEK respectively, which paradoxically can result in the activation of different proteins due to the complex interplay and compensatory mechanisms inherent in cellular signaling networks. PD98059 and U0126, by targeting MEK, modulate the MAPK/ERK pathway, influencing the activation state of proteins downstream.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Raises cAMP levels by activating adenylate cyclase, leading to PKA activation which can phosphorylate and activate various proteins. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Prevents cAMP breakdown by inhibiting phosphodiesterases, leading to sustained PKA activation and subsequent protein phosphorylation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Acts as a tyrosine kinase inhibitor but can also activate other kinases which may alter protein phosphorylation states. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates PKC, triggering phosphorylation cascades that can modify the activity of various proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium, activating calmodulin-dependent kinases that can phosphorylate and activate proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Disrupts calcium homeostasis by inhibiting SERCA, leading to calcium-mediated activation of kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that activates PKA, leading to phosphorylation and activation of certain proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, altering AKT signaling and affecting downstream protein activation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK1/2, modifying the MAPK/ERK pathway and influencing protein activation states. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that raises intracellular calcium, potentially activating calcium-sensitive proteins. | ||||||