Srs2 Activators
Chemicals that can indirectly influence the pathways or cellular processes related to Srs2 are mainly agents that induce DNA damage or inhibit the DNA damage response. Srs2, a helicase protein, plays a role in DNA repair and is particularly known for its role in homologous recombination suppression. Many chemicals, such as the ATR and ATM inhibitors, function by directly or indirectly causing DNA damage or replication stress, which can in turn activate the DNA repair mechanisms in which Srs2 is involved.
Others, like caffeine, have a more multifaceted mechanism, inhibiting multiple kinases involved in the DNA damage response. Another set of chemicals, like camptothecin and olaparib, target specific proteins or enzymes involved in DNA repair or replication. When these proteins or enzymes are inhibited, the cell is prompted to utilize alternative DNA repair mechanisms, which can possibly lead to increased Srs2 activity. DNA damaging agents like MMS, Zeocin, and radiation types, directly create breaks in the DNA, demanding an immediate cellular response, which can involve Srs2 activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Notoginsenoside R1 | 80418-24-2 | sc-205772 sc-205772A | 5 mg 10 mg | $141.00 $204.00 | ||
ATR (Ataxia telangiectasia and Rad3 related) is a key player in DNA damage response. Inhibiting ATR can cause DNA damage, potentially triggering Srs2 activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
ATM (Ataxia telangiectasia mutated) plays a role in the DNA damage response. Inhibition can potentially stimulate Srs2-mediated repair processes. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can inhibit ATM and ATR kinases, which might indirectly lead to Srs2 activation due to the DNA damage response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
This is a topoisomerase I inhibitor, inducing DNA breaks. These breaks can potentially stimulate Srs2 activity. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
It inhibits ribonucleotide reductase, leading to reduced dNTP pools and replication stress, which can potentially activate Srs2. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
A PARP inhibitor. PARP is involved in the DNA damage response, and its inhibition might indirectly activate Srs2. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
This is a DNA polymerase inhibitor, inducing replication stress, which can potentially activate Srs2. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Methyl methanesulfonate is a DNA damaging agent. DNA damage can potentially activate Srs2. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Induces DNA breaks, which can lead to potential activation of Srs2. | ||||||