SREB1 Activators
SREB1 Activators consist of a diverse array of chemical compounds that indirectly enhance the functional activity of SREB1 through various metabolic and transcriptional pathways. Compounds such as Forskolin, IBMX, and Adenosine predominantly operate through the cAMP-PKA axis, by either stimulating the production of cAMP or inhibiting its degradation, leading to enhanced SREB1 activity via the phosphorylation of downstream targets. Similarly, compounds that target PPAR receptors, including Rosiglitazone, Pioglitazone, Oleoylethanolamide, GW7647, EPA, and DHA, modulate lipid metabolism and indirectly enhance SREB1 activity. These PPAR activators serve to reprogram the transcriptional landscape of cells, thereby influencing lipid homeostasis in a manner that promotes SREB1's functional roles. Additionally, Metformin and AICAR, both known to activate AMPK, shift metabolic pathways in favor of processes that SREB1 is intricately connected to, thereby augmenting its activity through a broader metabolic context.
The activation of SREB1 by these compounds is further complemented by Cholic Acid, which engages with nuclear receptors such as FXR that govern the expression of genes involved in lipid metabolism, thus potentially enhancing SREB1's role within this regulatory framework. The interplay between these activators and SREB1 underscores the complexity of cellular metabolism where multiple pathways converge to regulate key proteins such as SREB1. By influencing the signaling and transcriptional networks that SREB1 is part of, these compounds collectively contribute to the enhanced functional activity of SREB1, shaping the metabolic landscape of the cell without necessitating the upregulation of SREB1 expression or direct activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby enhance the activity of SREB1, leading to its increased functional activity in metabolic regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) acts as a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increased cAMP levels indirectly enhance SREB1 activity by promoting PKA signaling, which can influence SREB1's function. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with adenosine receptors, which can activate adenylyl cyclase and increase cAMP production. This cAMP elevation, in turn, activates PKA and could enhance SREB1 activity through phosphorylation processes. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPAR-gamma agonist that influences the transcription of several genes involved in glucose and lipid metabolism. By activating PPAR-gamma, it can indirectly enhance the activity of SREB1 as part of the regulatory network controlling lipid metabolism. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Similar to Rosiglitazone, Pioglitazone activates PPAR-gamma and indirectly enhances SREB1 activity by modulating gene expression patterns involved in lipid homeostasis, which can influence SREB1's regulatory roles. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) activates AMP-activated protein kinase (AMPK), which can regulate metabolic pathways that SREB1 is involved in, thus indirectly enhancing its activity through metabolic modulation. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which can lead to altered metabolic states that indirectly enhance SREB1 activity by changing the regulatory network of glucose and lipid metabolism that SREB1 is part of. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
Oleoylethanolamide is a naturally occurring ethanolamide lipid that activates PPAR-alpha. Activation of PPAR-alpha can lead to an enhancement of SREB1 activity by altering lipid metabolism regulatory networks. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647 is a potent PPAR-alpha agonist that, by activating PPAR-alpha, can modulate lipid metabolism and indirectly enhance the activity of SREB1 through alterations in the metabolic regulatory network. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that can activate PPARs and thereby modulate lipid metabolism, indirectly enhancing SREB1 activity by influencing its role in the regulatory network. | ||||||