SREB1 Antibody (H-6): sc-393454

SREB1 Antibody (H-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects SREB1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SREB1 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SREB1 protein, also known as GPR27 (G protein-coupled receptor 27), is a member of the super conserved receptor expressed in brain subfamily of G protein-coupled receptors, which are crucial for mediating cell signaling in response to external stimuli. SREB1 is predominantly expressed in the central nervous system, where SREB1 plays a significant role in neuronal communication and may function as an amine-like receptor. SREB1 structure features seven transmembrane domains and extracellular loops that are subject to glycosylation, which is essential for maintaining receptor stability and function. These extracellular loops contain conserved cysteine residues that form disulfide bonds, further stabilizing the receptor′s conformation. Understanding SREB1 structure and function is vital, as such knowledge may provide insights into SREB1′s role in neurobiology and potential implications in neurological disorders.

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SREB1 Antibody (H-6) References:

1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.  |  Matsumoto, M., et al. 2000. Biochem Biophys Res Commun. 272: 576-82. PMID: 10833454
2. Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands.  |  Joost, P. and Methner, A. 2002. Genome Biol. 3: RESEARCH0063. PMID: 12429062
3. Molecular characterisation of a 15 Mb constitutional de novo interstitial deletion of chromosome 3p in a boy with developmental delay and congenital anomalies.  |  Petek, E., et al. 2003. J Hum Genet. 48: 283-287. PMID: 12836054
4. Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex.  |  Hellebrand, S., et al. 2001. Brain Res Gene Expr Patterns. 1: 13-6. PMID: 15018813
5. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain.  |  Matsumoto, M., et al. 2005. Brain Res Mol Brain Res. 138: 58-69. PMID: 15893849
6. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.  |  Kisseleva, T. and Brenner, DA. 2019. Cell Metab. 30: 850-852. PMID: 31693880
7. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition.  |  El-Derany, MO. and AbdelHamid, SG. 2021. Biochem Pharmacol. 190: 114624. PMID: 34052187
8. Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological Cancer.  |  Vasuki, KA. and Christy, HJ. 2022. Appl Biochem Biotechnol. 194: 407-433. PMID: 34817806
9. Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts.  |  Bayrak, A., et al. 2022. Future Med Chem. 14: 899-913. PMID: 35535715
10. Proximity Interactome Analysis of Super Conserved Receptors Expressed in the Brain Identifies EPB41L2, SLC3A2, and LRBA as Main Partners.  |  Kaafarani, A., et al. 2023. Cells. 12: PMID: 37998360
11. Spatial and quantitative gene expression analysis of SREB receptors in the gonads of green-spotted pufferfish (Dichotomyctere nigroviridis).  |  Breton, TS., et al. 2025. Gen Comp Endocrinol. 360: 114641. PMID: 39536984
12. Discovery of three novel G-protein-coupled receptor genes.  |  O'Dowd, BF., et al. 1998. Genomics. 47: 310-3. PMID: 9479505

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SREB1 Antibody (H-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SREB1 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SREB1 Antibody (H-6) Specifications

Alternate Product Name: SREB1

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 341-356

Epitope Target: SREB1

Epitope Species: human

Product Reactivity/Detection: SREB1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SREB1 Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin