Date published: 2025-11-28

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SR-7 Activators

SR-7 Activators are a specialized suite of chemical compounds that influence various intracellular signaling pathways to indirectly enhance the functional activity of the protein SR-7. Forskolin, by increasing adenylyl cyclase activity, raises intracellular cyclic AMP (cAMP) levels, leading to the activation of protein kinase A (PKA). SR-7 is a substrate of PKA or is regulated by PKA-mediated phosphorylation, this would result in its enhanced activity. Similarly, the direct provision of cAMP or its stable analog dibutyryl cAMP (db-cAMP) also activates PKA, potentially leading to the phosphorylation and subsequent activation of SR-7. Ionomycin, through its action as a calcium ionophore, elevates intracellular calcium concentrations, which may activate calcium-dependent protein kinases, such as calmodulin-dependent kinase (CaMK), that could phosphorylate SR-7. Further contributing to the activity enhancement of SR-7 are compounds that inhibit the dephosphorylation of proteins. Sodium orthovanadate, as a phosphatase inhibitor, could sustain the phosphorylation state of SR-7, while okadaic acid and calyculin A inhibit protein phosphatases PP1 and PP2A, respectively, thereby potentially maintaining SR-7 in an active phosphorylated form. Insulin's engagement with its receptor triggers the PI3K/Akt signaling pathway, which could enhance SR-7 activity. Anisomycin, by activating stress-activated protein kinases such as JNK and p38, might enhance the activity of SR-7. Lastly, S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide, which activates guanylyl cyclase to increase cGMP levels, and may enhance SR-7 activity through protein kinase G (PKG) dependent mechanisms, assuming SR-7 is a target of PKG.

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Items 1 to 10 of 18 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

LP 44

824958-12-5sc-224044
sc-224044A
10 mg
50 mg
$117.00
$667.00
(0)

LP 44, an SR-7 activator, exhibits remarkable reactivity due to its unique structural features. Its specific arrangement of functional groups enhances its ability to engage in nucleophilic attacks, leading to accelerated reaction kinetics. The compound's inherent polarity and steric properties facilitate distinct molecular interactions, allowing it to stabilize transition states effectively. This behavior promotes diverse reaction pathways, making LP 44 a versatile participant in various chemical processes.

WAY 629 hydrochloride

57756-45-3sc-204393
sc-204393A
10 mg
50 mg
$129.00
$548.00
(0)

WAY 629 hydrochloride, as an SR-7 activator, showcases distinctive molecular characteristics that enhance its reactivity. Its unique electronic configuration allows for efficient electron transfer, promoting rapid reaction kinetics. The compound's ability to form strong hydrogen bonds contributes to its stability in solution, while its specific steric arrangement enables selective interactions with substrates. This facilitates the exploration of alternative reaction pathways, underscoring its role in complex chemical transformations.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylyl cyclase, increasing the levels of cyclic AMP (cAMP) in cells. Elevated cAMP can lead to the activation of protein kinase A (PKA), which in turn can phosphorylate and enhance the activity of SR-7 if SR-7 is a PKA substrate or is regulated by PKA phosphorylation.

Fluperlapine

67121-76-0sc-201119
sc-201119A
sc-201119B
1 mg
5 mg
10 mg
$51.00
$232.00
$408.00
2
(1)

Fluperlapine, functioning as an SR-7 activator, exhibits remarkable molecular dynamics that influence its reactivity profile. Its unique spatial orientation and polar functional groups facilitate specific intermolecular interactions, enhancing selectivity in chemical reactions. The compound's propensity to engage in resonance stabilization allows for diverse reaction mechanisms, while its solubility characteristics promote effective diffusion in various environments, paving the way for innovative synthetic applications.

Adenosine 3′,5′-cyclic monophosphate

60-92-4sc-217584
sc-217584A
sc-217584B
sc-217584C
sc-217584D
sc-217584E
100 mg
250 mg
5 g
10 g
25 g
50 g
$114.00
$175.00
$260.00
$362.00
$617.00
$1127.00
(1)

cAMP is a second messenger important in many biological processes. cAMP directly activates PKA, which may then phosphorylate SR-7, leading to its enhanced functional activity.

5-Carboxamidotryptamine maleate

74885-09-9sc-203477
sc-203477A
5 mg
25 mg
$302.00
$1086.00
2
(0)

5-Carboxamidotryptamine maleate, as an SR-7 activator, showcases intriguing electronic properties that drive its reactivity. The compound's ability to form hydrogen bonds and engage in π-π stacking interactions enhances its affinity for target sites, influencing downstream signaling pathways. Its distinct steric configuration allows for selective binding, while the presence of carboxamide groups contributes to its solubility and stability in diverse chemical environments, facilitating unique reaction kinetics.

AS 19

1000578-26-6sc-203826
sc-203826A
1 mg
10 mg
$215.00
$849.00
1
(1)

AS 19, functioning as an SR-7 activator, exhibits remarkable electrostatic interactions that enhance its reactivity profile. The compound's unique structural features promote effective coordination with metal ions, influencing catalytic pathways. Its ability to undergo rapid conformational changes allows for dynamic interactions with biological targets, while the presence of halide substituents modulates its reactivity, leading to distinct kinetic behaviors in various environments.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases like calmodulin-dependent kinase (CaMK), which could phosphorylate and activate SR-7 if it is part of a calcium-dependent signaling pathway.

LP 12 hydrochloride

sc-361234
sc-361234A
10 mg
50 mg
$169.00
$712.00
1
(0)

LP 12 hydrochloride, as an SR-7 activator, showcases distinctive hydrogen bonding capabilities that significantly influence its reactivity. The compound's specific steric arrangement facilitates selective interactions with substrates, enhancing reaction rates. Its unique electronic properties allow for efficient charge transfer, while the presence of halide groups introduces variability in solubility and stability, affecting its behavior in diverse chemical environments.

5-Carboxamidotryptamine maleate salt

74885-72-6sc-252258
5 mg
$209.00
(0)

5-Carboxamidotryptamine maleate salt hemiethanolate functions as an SR-7 activator, exhibiting remarkable conformational flexibility that enhances its interaction with target proteins. The compound's ability to form transient complexes through π-π stacking and hydrophobic interactions contributes to its kinetic profile, promoting rapid activation. Additionally, its solvation dynamics play a crucial role in modulating reactivity, allowing for tailored responses in various chemical contexts.