Molecular structure of Fluperlapine, CAS Number: 67121-76-0
Fluperlapine (CAS 67121-76-0)
See product citations (2)
Application:
Fluperlapine is an agonist of the serotonin 5-HT6/5-HT7 receptors
CAS Number:
67121-76-0
Purity:
≥95%
Molecular Weight:
309.40
Molecular Formula:
C19H20FN3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluperlapine is an agonist of the serotonin 5-HT6/5-HT7 receptors. Agonism of the 5-HT6/5-HT7 receptors by Fluperlapine has been correlated to sedative effects. Fluperlapine is described to function similarly to Clozapine (sc-200402), and Fluperlapine is also described to be relatively resistant to chemical and biochemical oxidation as compared to Clozapine.
Fluperlapine (CAS 67121-76-0) References
- Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis. | Lai, WG., et al. 2000. Drug Metab Dispos. 28: 255-63. PMID: 10681368
- NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists. | Andersen, PH., et al. 1992. Eur J Pharmacol. 219: 45-52. PMID: 1397049
- Effects of acute and long-term treatment with neuroleptics on regional telencephalic neurotensin levels in the male rat. | Frey, P., et al. 1986. Neurochem Int. 8: 429-34. PMID: 20493074
- Neurotensin concentrations in rat striatum and nucleus accumbens: Further studies of their regulation. | Frey, P., et al. 1988. Neurochem Int. 12: 33-8. PMID: 20501200
- Metabolism of fluperlapine by cytochrome P450-dependent and flavin-dependent monooxygenases in continuous cultures of rat and human cells. | Fischer, V. and Wiebel, FJ. 1990. Biochem Pharmacol. 39: 1327-33. PMID: 2322314
- The effects of clozapine and fluperlapine on the in vivo release and metabolism of dopamine in the striatum and in the prefrontal cortex of freely moving rats. | Imperato, A. and Angelucci, L. 1989. Psychopharmacol Bull. 25: 383-9. PMID: 2576318
- Comparison of the pharmacological characteristics of [3H]raclopride and [3H]SCH 23390 binding to dopamine receptors in vivo in mouse brain. | Andersen, PH. 1988. Eur J Pharmacol. 146: 113-20. PMID: 2895008
- Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat. | Dain, JG. and Jaffe, JM. 1988. Drug Metab Dispos. 16: 238-42. PMID: 2898340
- Effects of fluperlapine on dopaminergic systems in rat brain. | Burki, HR. 1986. Psychopharmacology (Berl). 89: 77-84. PMID: 2942961
- Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat. | Gudelsky, GA., et al. 1987. J Neural Transm. 68: 227-40. PMID: 3104536
- Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis. | Sernoskie, SC., et al. 2022. Toxicol Sci. 186: 70-82. PMID: 34935985
- Pharmaco-EEG studies with fluperlapine. | Matejcek, M., et al. 1984. Arzneimittelforschung. 34: 114-20. PMID: 6145426
- Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. | Roth, BL., et al. 1994. J Pharmacol Exp Ther. 268: 1403-10. PMID: 7908055
- Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity. | Farber, NB., et al. 1996. Schizophr Res. 21: 33-7. PMID: 8998274
Activator of:
SR-6, and SR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluperlapine, 1 mg | sc-201119 | 1 mg | $51.00 | |||
Fluperlapine, 5 mg | sc-201119A | 5 mg | $232.00 | |||
Fluperlapine, 10 mg | sc-201119B | 10 mg | $408.00 |