Molecular structure of 5-Carboxamidotryptamine maleate, CAS Number: 74885-09-9
5-Carboxamidotryptamine maleate (CAS 74885-09-9)
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Alternate Names:
5-CT; AH-21467
Application:
5-Carboxamidotryptamine maleate is an agonist of the 5-HT1 receptors
CAS Number:
74885-09-9
Molecular Weight:
319.32
Molecular Formula:
C11H13N3O•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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5-Carboxamidotryptamine maleate (5-CT) is a serotonin analog that has been widely used in scientific research to study its effects on the central nervous system. It is a 5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors. Activation of 5-HT1 receptors may act to reduce the release of neurotransmitters such as dopamine and norepinephrine, while activation of 5-HT2 receptors may act to increase the release of these neurotransmitters. 5-Carboxamidotryptamine maleate has also been shown to modulate calcium levels in cells.
5-Carboxamidotryptamine maleate (CAS 74885-09-9) References
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- Effects of serotonin and serotonin analogs on posture and agonistic behavior in crayfish. | Tierney, AJ. and Mangiamele, LA. 2001. J Comp Physiol A. 187: 757-67. PMID: 11800033
- 5-HT receptors couple to activation of Akt, but not extracellular-regulated kinase (ERK), in cultured hippocampal neurons. | Cowen, DS., et al. 2005. J Neurochem. 93: 910-7. PMID: 15857394
- Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline. | Otmakhova, NA., et al. 2005. J Neurophysiol. 94: 1413-22. PMID: 15888529
- Intracellular cAMP and calcium signaling by serotonin in mouse cumulus-oocyte complexes. | Amireault, P. and Dubé, F. 2005. Mol Pharmacol. 68: 1678-87. PMID: 16131615
- Serotonin activates presynaptic and postsynaptic receptors in rat globus pallidus. | Hashimoto, K. and Kita, H. 2008. J Neurophysiol. 99: 1723-32. PMID: 18234984
- Evidence that 5-hydroxytryptamine(7) receptors play a role in the mediation of afferent transmission within the nucleus tractus solitarius in anaesthetized rats. | Oskutyte, D., et al. 2009. Br J Pharmacol. 158: 1387-94. PMID: 19785653
- Peripheral 5-HT1A and 5-HT7 serotonergic receptors modulate parasympathetic neurotransmission in long-term diabetic rats. | Restrepo, B., et al. 2010. Exp Diabetes Res. 2010: 686734. PMID: 21403818
- 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. | García-Pedraza, JÁ., et al. 2015. Vascul Pharmacol. 72: 172-80. PMID: 26003124
- 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. | García-Pedraza, JA., et al. 2016. Vascul Pharmacol. 79: 51-59. PMID: 26586311
- Inhibition of N- and P-type calcium currents and the after-hyperpolarization in rat motoneurones by serotonin. | Bayliss, DA., et al. 1995. J Physiol. 485 (Pt 3): 635-47. PMID: 7562606
- Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. | Carter, D., et al. 1995. Eur J Pharmacol. 280: 243-50. PMID: 8566092
Activator of:
G α o, SR-1A, SR-1B, SR-1D, SR-5A, and SR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Carboxamidotryptamine maleate, 5 mg | sc-203477 | 5 mg | $302.00 | |||
5-Carboxamidotryptamine maleate, 25 mg | sc-203477A | 25 mg | $1086.00 |