Date published: 2026-2-10

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WAY 629 hydrochloride (CAS 57756-45-3)

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Application:
WAY 629 hydrochloride is a selective SR-2C agonist
CAS Number:
57756-45-3
Purity:
>98%
Molecular Weight:
262.78
Molecular Formula:
C15H18N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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WAY 629 hydrochloride is a selective SR-2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant SR-2C, SR-2A, SR-6 and SR-7, respectively. WAY 629 hydrochloride stimulates intracellular Ca2+ mobilization in CHO cells expressing human SR-2C (EC50 = 72 nM).


WAY 629 hydrochloride (CAS 57756-45-3) References

  1. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.  |  Sabb, AL., et al. 2004. Bioorg Med Chem Lett. 14: 2603-7. PMID: 15109661
  2. Innovative approaches for the development of antidepressant drugs: current and future strategies.  |  Schechter, LE., et al. 2005. NeuroRx. 2: 590-611. PMID: 16489368
  3. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence.  |  Bubar, MJ. and Cunningham, KA. 2006. Curr Top Med Chem. 6: 1971-85. PMID: 17017968
  4. Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents.  |  Rosenzweig-Lipson, S., et al. 2007. Psychopharmacology (Berl). 192: 159-70. PMID: 17297636
  5. Stress impairs 5-HT2A receptor-mediated serotonergic facilitation of GABA release in juvenile rat basolateral amygdala.  |  Jiang, X., et al. 2009. Neuropsychopharmacology. 34: 410-23. PMID: 18536707
  6. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.  |  Cho, SJ., et al. 2009. J Med Chem. 52: 1885-902. PMID: 19284718
  7. HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.  |  Kozikowski, AP., et al. 2010. ChemMedChem. 5: 1221-5. PMID: 20533502
  8. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.  |  Daftary, SS., et al. 2012. Neuroscience. 224: 125-34. PMID: 22917617
  9. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair.  |  Aoki, M., et al. 2016. Eur J Neurosci. 43: 1219-28. PMID: 26950265
  10. Serotonin Regulates the Firing of Principal Cells of the Subiculum by Inhibiting a T-type Ca2+ Current.  |  Petersen, AV., et al. 2017. Front Cell Neurosci. 11: 60. PMID: 28326015
  11. High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.  |  Ghasemi, F., et al. 2018. Oncotarget. 9: 26064-26071. PMID: 29899842
  12. Neuropeptide Y neurons in the nucleus accumbens modulate anxiety-like behavior.  |  Yamada, S., et al. 2020. Exp Neurol. 327: 113216. PMID: 32014439
  13. Serotonin activates paraventricular thalamic neurons through direct depolarization and indirect disinhibition from zona incerta.  |  Ye, Q. and Zhang, X. 2021. J Physiol. 599: 4883-4900. PMID: 34510418
  14. Raphe serotonin projections dynamically regulate feeding behavior through targeting inhibitory circuits from rostral zona incerta to paraventricular thalamus.  |  Ye, Q., et al. 2022. Mol Metab. 66: 101634. PMID: 36351530

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

WAY 629 hydrochloride, 10 mg

sc-204393
10 mg
$129.00

WAY 629 hydrochloride, 50 mg

sc-204393A
50 mg
$548.00