Spot 14 Inhibitors
Spot 14 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the Spot 14 protein, also known as S14. Spot 14 is a transcriptional regulator and a key player in lipid metabolism and fatty acid synthesis. It plays a critical role in regulating the expression of various enzymes involved in de novo lipogenesis, a process that generates new fatty acids from non-lipid precursors. Inhibitors designed to target Spot 14 are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein's role in lipid homeostasis.
The development of Spot 14 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with Spot 14 and modulate its activity as a transcriptional regulator. By inhibiting Spot 14, these compounds can interfere with its ability to control the expression of genes involved in fatty acid synthesis and lipid metabolism. Researchers use Spot 14 inhibitors to explore the intricate roles played by this protein in maintaining cellular lipid balance, uncovering its contributions to lipid storage, membrane formation, and overall lipid metabolism. Furthermore, these inhibitors serve as valuable tools for dissecting the broader network of cellular pathways involving lipid synthesis and regulation, contributing to our understanding of fundamental cell biology mechanisms and providing insights into avenues for further scientific exploration.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
As an antiarrhythmic agent that also affects thyroid hormone synthesis, amiodarone could potentially alter the expression of Spot 14 by impacting thyroid hormone availability. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole inhibits cytochrome P450 enzymes and could disrupt thyroid hormone synthesis, which might indirectly reduce the expression of thyroid hormone-responsive genes like Spot 14. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $57.00 | 2 | |
Some phthalates are known endocrine disruptors which might interfere with thyroid hormone pathways, potentially decreasing Spot 14 expression by altering thyroid hormone signaling. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
This thyroid hormone synthesis inhibitor can decrease circulating thyroid hormone levels, which could hypothetically down-regulate thyroid hormone-inducible proteins like Spot 14. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Methimazole inhibits the synthesis of thyroid hormones, which in turn could lead to a reduction in the expression of thyroid hormone-responsive genes such as Spot 14. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to influence lipid metabolism and might affect the expression of genes like Spot 14 involved in this process through its action on SIRT1 and other metabolic regulators. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, can act as an inhibitor of sirtuins and potentially influence the expression of genes related to lipid metabolism, including Spot 14, by modifying the cellular NAD+ levels. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $47.00 $156.00 $171.00 $525.00 $941.00 | 4 | |
As an antiandrogen that can affect gene transcription, hydroxyflutamide may indirectly influence the expression of a broad range of proteins, including those responsive to thyroid hormone like Spot 14. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a flavonoid that exhibits anti-inflammatory properties and may impact gene expression by modulating various signaling pathways, which could theoretically reduce the expression of Spot 14. | ||||||
Diallyl sulfide | 592-88-1 | sc-204718 sc-204718A | 25 g 100 g | $42.00 $106.00 | 3 | |
Found in garlic, diallyl sulfide is known to affect the expression of various enzymes and could potentially have an impact on thyroid hormone metabolism, thereby affecting Spot 14 expression. | ||||||