Spot 14 Activators
Spot 14 activators represent a unique and specialized class of chemical compounds that play a crucial role in regulating lipid metabolism and cellular energy homeostasis. These molecules are primarily associated with the modulation of lipid synthesis and storage within cells. Spot 14, also known as S14, is a protein primarily found in the liver, adipose tissue, and mammary glands, and it is essential for the control of fatty acid synthesis and energy storage in these tissues. Spot 14 activators are small molecules that have the ability to enhance the expression and activity of Spot 14 protein, thereby influencing lipid metabolism pathways.
Spot 14 activators function by binding to specific receptors or molecular targets within the cell, leading to the upregulation of Spot 14 gene expression. This, in turn, promotes the transcription of key enzymes involved in fatty acid biosynthesis and lipogenesis. Consequently, the activation of Spot 14 by these compounds results in increased synthesis of fatty acids and their subsequent incorporation into lipid droplets, contributing to energy storage and adipocyte differentiation. While the exact mechanisms of action of Spot 14 activators may vary among different compounds, they collectively play a pivotal role in the intricate regulation of lipid metabolism and cellular energy balance, making them an essential area of study in the field of metabolic research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate increases Spot 14 activity by activating peroxisome proliferator-activated receptor alpha (PPAR-α), a nuclear receptor involved in lipid metabolism. PPAR-α activation indirectly enhances Spot 14 expression by modulating the transcription of genes related to lipid metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases Spot 14 activation by elevating intracellular levels of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA influences Spot 14 expression through downstream signaling pathways associated with lipid metabolism. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates Spot 14 by acting as an activator of AMP-activated protein kinase (AMPK), a cellular energy sensor. AMPK activation indirectly enhances Spot 14 activity by modulating energy-related pathways that influence lipid metabolism. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone increases Spot 14 activity by functioning as an agent in research that activates peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor involved in insulin sensitivity and glucose metabolism. PPAR-γ activation indirectly enhances Spot 14 expression by regulating genes associated with metabolism. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA increases Spot 14 activation by affecting lipid metabolism. It influences Spot 14 by regulating genes involved in fatty acid synthesis and triglyceride storage. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
DHA increases Spot 14 activity similarly to EPA by impacting lipid metabolism. It influences Spot 14 by regulating genes associated with fatty acid synthesis and storage. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $35.00 $74.00 | 2 | |
Thyroxine directly activates Spot 14 by binding to thyroid hormone receptors. This activation influences the transcription of genes related to lipid metabolism, including Spot 14. | ||||||
L-3,3′,5-Triiodothyronine, Sodium Salt | 55-06-1 | sc-205725 | 250 mg | $115.00 | ||
Triiodothyronine directly activates Spot 14 through thyroid hormone receptors. It plays a pivotal role in regulating genes involved in lipid metabolism, increasing Spot 14 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA increases Spot 14 activation indirectly by affecting retinoic acid receptors (RARs), which regulate gene transcription. Changes in RAR activity enhance genes associated with lipid metabolism, including Spot 14. | ||||||