Spir-2 Activators
Spir-2 Activators belong to a distinct chemical class characterized by their ability to modulate specific cellular processes. These compounds target the Spir-2 protein, a crucial component in various cellular pathways, and facilitate its activation. Spir-2 itself is an essential regulator of cellular functions, playing a pivotal role in processes such as cell migration, cytoskeletal organization, and intracellular signal transduction. The activation of Spir-2 by its corresponding activators can have profound effects on cell behavior, particularly in the context of cell motility and structural dynamics.
Spir-2 Activators interact with the Spir-2 protein to induce conformational changes that enhance its functional activity. This activation typically leads to a cascade of downstream effects within the cell. For instance, Spir-2 Activators can promote actin polymerization, which is vital for cell shape changes and movement. Additionally, they may influence the formation of specialized cellular structures, such as filopodia and lamellipodia, which are essential for processes like cell migration and adhesion. The precise mechanisms by which Spir-2 Activators achieve these effects are a subject of ongoing research, but their ability to modulate Spir-2 activity opens up new avenues for understanding and potentially controlling various cellular processes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to activation of PKA. PKA phosphorylates various targets that could enhance Spir-2's activity in actin nucleation and cytoskeleton organization. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates multiple targets and could enhance Spir-2's role in modulating the actin cytoskeleton through downstream effects on actin-binding proteins. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P acts through G-protein coupled receptors to activate downstream kinases, potentially influencing Spir-2's interaction with actin and its role in nucleating actin filaments. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation stimulates PI3K signaling, which could increase the activity of proteins involved in actin dynamics, potentially enhancing Spir-2's function in actin filament nucleation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, leading to stabilization of microtubules, which could affect Spir-2's role in modulating the cytoskeleton and interacting with actin filaments. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
As a cAMP analog, 8-Bromo-cAMP can activate PKA, potentially enhancing Spir-2's role in the actin nucleation process and cytoskeleton organization by modulating actin-binding proteins. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a serine/threonine phosphatase inhibitor, which could lead to an increase in phosphorylation status of proteins that modulate actin dynamics, thereby enhancing the activity of Spir-2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
As another cAMP analog, Dibutyryl-cAMP activates PKA, which could enhance Spir-2's function in actin polymerization and cytoskeletal rearrangements. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent kinases, potentially enhancing Spir-2's role in actin filament nucleation. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can lead to actin polymerization, which may increase the need for Spir-2's actin nucleation activity. | ||||||