Spir-2 Inhibitors
Spir-2 inhibitors represent a class of chemical compounds designed to modulate the activity of a specific target known as Spir-2, a protein with crucial cellular functions. These inhibitors are meticulously crafted to interact with Spir-2, altering its biological activity and influencing downstream cellular processes. Spir-2, short for Spire-2, is a member of the Spire family of actin nucleation factors that play a pivotal role in regulating the dynamics of the cytoskeleton-a complex network of protein filaments essential for maintaining cell shape and enabling various cellular functions.
Spir-2 inhibitors is characterized by specific functional groups and molecular motifs that facilitate binding to Spir-2. Through this interaction, Spir-2 inhibitors can modulate the nucleation and polymerization of actin filaments, which, in turn, affects cellular processes such as cell motility, intracellular transport, and cell division. The design and development of Spir-2 inhibitors involve a comprehensive understanding of the three-dimensional structure of Spir-2 and the intricate biochemical pathways it participates in. Researchers in the field of molecular pharmacology aim to optimize the potency and selectivity of these inhibitors, ensuring minimal off-target effects while maximizing their impact on Spir-2-mediated cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin monomers and prevents their polymerization, thus indirectly affecting SPIRE2 activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds to the barbed ends of actin filaments, blocking elongation and potentially altering SPIRE2's function. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Severs actin filaments and prevents reannealing, likely influencing SPIRE2 mediated actin nucleation. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments, which may indirectly affect SPIRE2's nucleation activity. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits the Arp2/3 complex, potentially altering the actin nucleation process where SPIRE2 is involved. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II ATPase activity, potentially affecting actin dynamics and SPIRE2 interaction. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin-mediated actin nucleation, possibly altering the cellular processes that involve SPIRE2. | ||||||