Molecular structure of CK 666, CAS Number: 442633-00-3
CK 666 (CAS 442633-00-3)
See product citations (5)
Alternate Names:
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide; CK-0944666; CK-666
Application:
CK 666 is an inhibitor of the Arp2/3 complex
CAS Number:
442633-00-3
Purity:
≥99%
Molecular Weight:
296.34
Molecular Formula:
C18H17FN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CK 666 is a small molecule inhibitor known for its selective action against the Arp2/3 complex, which plays a vital role in the regulation of the actin cytoskeleton in cells. In biological research, CK 666 is used to investigate the dynamics of actin polymerization and to understand the molecular basis of cell motility, endocytosis, and the formation of cell protrusions. By inhibiting the Arp2/3 complex, researchers can study the impact on various cellular processes that are dependent on actin filament formation. CK 666 is also instrumental in cell biology studies aimed at dissecting the pathways involved in the assembly and disassembly of actin networks. Additionally, it serves as useful in the development of new approaches to study the role of the cytoskeleton in cell division and signaling.
CK 666 (CAS 442633-00-3) References
- Characterization of two classes of small molecule inhibitors of Arp2/3 complex. | Nolen, BJ., et al. 2009. Nature. 460: 1031-4. PMID: 19648907
- Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. | Hetrick, B., et al. 2013. Chem Biol. 20: 701-12. PMID: 23623350
- Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells. | Ilatovskaya, DV., et al. 2013. Cell Tissue Res. 354: 783-92. PMID: 24036843
- Methamphetamine-induced occludin endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement. | Park, M., et al. 2013. J Biol Chem. 288: 33324-34. PMID: 24081143
- ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrity. | Abu Taha, A., et al. 2014. Mol Biol Cell. 25: 245-56. PMID: 24227887
- GMFβ controls branched actin content and lamellipodial retraction in fibroblasts. | Haynes, EM., et al. 2015. J Cell Biol. 209: 803-12. PMID: 26101216
- Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala. | Basu, S., et al. 2016. eNeuro. 3: PMID: 27957528
- The ARP 2/3 complex mediates endothelial barrier function and recovery. | Belvitch, P., et al. 2017. Pulm Circ. 7: 200-210. PMID: 28680579
- Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections. | Dhanda, AS., et al. 2018. mBio. 9: PMID: 29636431
- Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation. | Sun, YY., et al. 2019. Invest Ophthalmol Vis Sci. 60: 843-851. PMID: 30807639
- Long-term memory is maintained by continuous activity of Arp2/3 in lateral amygdala. | Basu, S., et al. 2020. Neurobiol Learn Mem. 167: 107115. PMID: 31733301
- Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway. | Liu, CS., et al. 2021. Am J Physiol Renal Physiol. 321: F179-F194. PMID: 34180716
- Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666. | Fokin, AI., et al. 2022. Front Pharmacol. 13: 896994. PMID: 35707404
Inhibitor of:
α-actinin-3, α-actinin-4, α-centractin, αPIX, γ1-Adaptin, 3110003A17Rik, 4921517D21Rik, 6720456B07Rik, Abi-1, ABLIM1, ABLIM2, Abp1, ACTBL1, ACTC1, ACTG1, ACTG2, Actin related protein 2/3 (ARP2/3), ACTL10, ACTL7B, ACTR10, Adducin β, AFAP-1L2, AGAP1, ANK-1, ARHGEF10, ARHGEF18, ARL5A, ARL9, Arp2, Arp3β, BC055111, beta-Actin, BRAG2, C20orf134, Calponin 2, Calponin 3, CAP1, CCDC38, CCDC53, CLP36, COBLL1, Cofilin 1, Cofilin 2, Cordon-bleu, Coronin 1C, Coronin 2A, Cylicin-2, D6Wsu116e, Dab2, DDEF2, DDEFL1, DIAPH3, EG231836, EG432995, EG546400, EHBP1L1, Espin, EVL, Ezrin, FAM160A2, FAM21A, FAM21C, FAM39E, FBLIM1, FBP21, FHOD1, Filamin 3, Flightless I, FMNL3, Formin Like (FMNL1, FMNL2), Frabin, Gas8, girdin, Gm14137, Gm732, Gm949, GS2, HIP-55, HSPC300, INF2, Intersectin-2, IPP, IRSp53, JMY, JRAB, KIAA1033, KLHDC9, L-Plastin, Lad, Lamellipodin, Las17, Leiomodin 3, LGN, LRCH3, LSP1, LURAP1, MACF1, Mena, MICAL, MICAL1, MIRAB13, Moesin, MORN1, MRTF-B, MSE55, Muscle Actin, Muskelin, MYBPH, MYH14, MYH4, MYH6, MYH7, MYL9, Myocardin, MyoD, Myosin, Myosin Ic, Myosin Ig, Myosin Va, Myosin Vc, Myosin X, Myosin-XVA, Myotilin, N-WASP, NCKAP5L, Nebulette, Nebulin, NET1, Neuron navigator 2, ORF19, PACSIN3, palladin, PAR-6, PARD3A, PARD6G, PARV (parvin), Parvin beta, PCDHGA11, periaxin, PIPK III, plakophilin 4, PLEKHH3, POF1B, POP1, POR1, Profilin-4, PSD, Rab 23, Rab 3A, Rab 40AL, Rab 9B, RGNEF, Rho C, Rho F, RHOBTB3, RILPL2, RINL, RNF103-CHMP3, RPGRIP1L, SEMA4C, Septin 10, Septin 12, SERINC5, SH3TC1, SHD1, shootin1, SHROOM1, SHROOM4, Skn-1i, SMAP1, Smooth Muscle Actin, SNX5, spectrin α I, Spir-1, Spir-2, Strumpellin, Supervillin, SWAP-70, Synaptopodin, T-Plastin, Talin-1, TBC1D12, Titin, Tmsb15b1, TOCA-1, Tropomyosin, Tropomyosin β, Tropomyosin 4, UNC45B, Veli1, Vimentin, VPS13A, WAVE2, WAVE3, Wip1, WIRE, WNT (Wingless Int-1), Wnt-5a, Xinα, Xinβ, and Zyxin.Activator of:
γPAK, AIP5, ArgBP2, ARHGAP30, ARHGAP39, ARHGAP42, Arp3C, Arp7, ARPC5L, BC055107, CapZ-β, Cdc42EP4, Centaurin α1, Coronin 1B, Coronin 7, COTL1, DAAM2, Desmin, EG231836, EG432995, FCHSD1, FGD1, FHOD3, FNDC1, Gm732, GMF-β, HRF, IQGAP3, Kaptin, KRAP, LIMK-1, LOC553158, LOC642574, LURAP1L, MRTF-A, Myf-5, MYH9, Myosin VI, Myosin XVIIIb, PLEKHG6, RAb 19B, rhophilin-2, Septin 6, SPATA13, SRGAP1, SYDE1, Tβ-10, tropomodulin 1, tropomodulin 3, tropomodulin 4, Twinfilin-1, and WIP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CK 666, 10 mg | sc-361151 | 10 mg | $321.00 | |||
CK 666, 50 mg | sc-361151A | 50 mg | $1040.00 |