Spir-1 Activators represent a specific subset of chemical compounds that play a pivotal role in the biochemical orchestration that leads to the activation of Spir-1, a protein associated with the regulation of actin polymerization and thus, crucial for cytoskeletal organization and cellular dynamics. These activators function through a variety of intracellular signaling pathways, ultimately converging on mechanisms that enhance Spir-1 activity. For instance, some Spir-1 Activators may work by modulating the levels of secondary messengers within cells, which in turn can lead to the post-translational modifications of Spir-1 or its associated partners, thereby increasing its functional activity. Others may influence the binding affinities between Spir-1 and its substrates or binding partners, modifying the protein's conformational state to one that favors its active form.
The exact molecular mechanisms by which Spir-1 Activators exert their effects are diverse and reflect the complexity of cellular signaling networks. Certain activators may target upstream signaling molecules, resulting in a cascade of phosphorylation events that prime Spir-1 for enhanced activity. Conversely, some activators may inhibit negative regulatory pathways of Spir-1, thereby disinhibiting the protein and promoting its active state. Through such precise biochemical interactions, Spir-1 Activators facilitate the fine-tuned control of Spir-1, enabling its role in processes such as vesicle trafficking, organelle positioning, and the maintenance of cell morphology. The specificity of Spir-1 Activators lies in their ability to selectively influence Spir-1-related pathways without broadly affecting other signaling cascades, thereby maintaining cellular homeostasis while ensuring the targeted enhancement of Spir-1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn can enhance the actin nucleation activity of Spir-1 by promoting the formation of signaling complexes that stimulate actin polymerization. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which could phosphorylate downstream targets that interact with Spir-1, enhancing its activity in actin nucleation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits a range of kinases, potentially reducing negative regulation on Spir-1, thereby enhancing its role in actin cytoskeleton dynamics. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
As a bioactive lipid, it activates G-protein coupled receptors which may lead to downstream signaling events that enhance Spir-1 mediated actin nucleation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This PI3K inhibitor can lead to alterations in downstream signaling that may relieve inhibitory control on Spir-1, enhancing its activity in actin remodeling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Similar to LY294002, Wortmannin inhibits PI3K potentially shifting signaling pathways towards those that enhance Spir-1 activity in cytoskeletal organization. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
As an inhibitor of p38 MAPK, SB203580 might redirect signaling processes to enhance Spir-1's role in actin filament formation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Increases intracellular calcium concentration, potentially activating calcium-dependent proteins that interact with and enhance Spir-1 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
By increasing intracellular calcium stores, it could activate signaling cascades that facilitate Spir-1's function in actin polymerization. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
This tyrosine kinase inhibitor may reduce competition for tyrosine phosphorylation sites on proteins that associate with Spir-1, enhancing its activity in the actin cytoskeleton assembly. | ||||||