SPINK6 Inhibitors
Chemical inhibitors of SPINK6 can function through various mechanisms to inhibit the activity of this protein. E-64 serves as a potent, irreversible inhibitor of cysteine proteases, thus reducing the functional necessity for SPINK6 activity by inhibiting the proteolytic processes SPINK6 would typically regulate. Similarly, Gabexate Mesilate functions as a synthetic serine protease inhibitor, targeting enzymes like trypsin, thrombin, plasmin, and kallikrein. This broad inhibition of proteases diminishes the functional role of SPINK6 by making its inhibitory action on these enzymes redundant. Nafamostat Mesilate, with an inhibitory profile similar to Gabexate Mesilate, reduces the role of SPINK6 by precluding the protease activity that SPINK6 would normally regulate. AEBSF further contributes to this reduction by irreversibly inhibiting serine proteases, which are targets of SPINK6, thus diminishing the protein's functional role.
Aprotinin, a competitive serine protease inhibitor, suppresses the activity of proteases that SPINK6 is designed to regulate, reducing SPINK6's functional role by obviating its inhibitory action. Chymostatin specifically inhibits chymotrypsin, a serine protease, leading to a functional inhibition of SPINK6 by directly targeting the enzymes it acts upon. Leupeptin, inhibiting both serine and cysteine proteases, renders the inhibitory function of SPINK6 less necessary and thereby functionally reduces its activity within the cell. While Pepstatin A is an aspartyl protease inhibitor, its suppression of related proteolytic pathways can indirectly diminish the functional requirement for SPINK6. Phosphoramidon, a metalloprotease inhibitor, and PMSF, another serine protease inhibitor, both contribute to the inhibition of proteases in pathways regulated by SPINK6, effectively diminishing SPINK6's role in the cell. Sivelestat, though selectively inhibiting neutrophil elastase, can decrease the cellular demand for SPINK6 regulation by inhibiting related serine proteases. Lastly, 3,4-DCI impedes serine proteases that SPINK6 regulates, thus functionally reducing the activity of SPINK6 by making its regulatory action superfluous.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is a potent, irreversible cysteine protease inhibitor. Since SPINK6 is known to be a Kazal-type serine protease inhibitor, it is logical that inhibition of proteases which interact with SPINK6 would reduce the functional activity of SPINK6. By inhibiting these proteases, E-64 prevents the proteolytic cascade that SPINK6 would normally inhibit, thus functionally reducing the necessity for SPINK6 activity. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate Mesilate is a synthetic serine protease inhibitor. It inhibits various enzymes including trypsin, thrombin, plasmin, and kallikrein, thus, by extension, it would inhibit the proteolytic processes that SPINK6 is involved in, leading to a functional inhibition of SPINK6 since its role in inhibiting serine proteases becomes redundant. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
Nafamostat Mesilate is a synthetic serine protease inhibitor with a broad inhibitory profile. It would inhibit the enzymatic activity of proteases in the same biochemical pathway as SPINK6, reducing the functional role of SPINK6 by precluding the protease activity that SPINK6 would typically regulate. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
AEBSF is an irreversible serine protease inhibitor which, by inhibiting serine proteases that SPINK6 targets, would diminish the functional role of SPINK6 in inhibiting these enzymes. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
Aprotinin is a competitive serine protease inhibitor that would inhibit the activity of certain proteases that SPINK6 is designed to regulate, thereby diminishing the functional role of SPINK6 by making its inhibitory action unnecessary. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $153.00 $255.00 $627.00 $1163.00 $2225.00 | 3 | |
Chymostatin is a chymotrypsin inhibitor and, given that SPINK6 inhibits serine proteases like chymotrypsin, the use of Chymostatin would lead to a functional inhibition of SPINK6 by inhibiting the proteases it acts upon. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is an inhibitor of several serine and cysteine proteases. By inhibiting these proteases, Leupeptin would render the inhibitory function of SPINK6 less necessary, thus functionally reducing its activity. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $195.00 $620.00 | 8 | |
Phosphoramidon is a metalloprotease inhibitor that could inhibit proteases in related pathways to those regulated by SPINK6, potentially reducing the functional necessity of SPINK6 activity in the cell. | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $683.00 | 92 | |
PMSF is a serine protease inhibitor that would inhibit the activity of proteases targeted by SPINK6, thereby functionally reducing the need for SPINK6's inhibitory action. | ||||||
Sivelestat | 127373-66-4 | sc-203938 | 1 mg | $105.00 | 2 | |
Sivelestat is a selective neutrophil elastase inhibitor. Although SPINK6 is not known to inhibit elastase directly, the inhibition of related serine proteases by Sivelestat could lead to a decrease in the cellular demand for SPINK6's regulatory function. | ||||||