SPINK6 Activators
SPINK6 Activators encompass a diverse array of chemical compounds that bolster the activity of SPINK6 through several mechanisms, addressing the complex web of signaling that regulates tissue integrity and protease activity. Epigallocatechin gallate and Sulforaphane, for example, directly and indirectly fortify SPINK6's role by modulating the extracellular matrix and activating the Nrf2 pathway, respectively, hence maintaining an environment conducive to SPINK6's protease inhibitory action. Curcumin and Resveratrol exert their positive influence on SPINK6 by engaging with the NF-κB and sirtuin pathways, leading to the suppression of inflammation and enhancement of cell survival under stress, conditions under which SPINK6 is crucial. Similarly, Quercetin's interaction with the PI3K/Akt pathway and Retinoic Acid's influence on gene expression through its receptors may upregulate SPINK6, reinforcing cellular defenses against proteolytic damage.
The activity of SPINK6 is further sustained by compounds like Vitamin D3, which through its receptor-mediated gene expression, and Zinc, a cofactor essential for protein stability, both contribute to the integrity of cellular functions safeguarded by SPINK6. Lycopene and Ellagic Acid, with their antioxidant properties, support SPINK6 by mitigating oxidative stress and modulating inflammation, thus bolstering the tissue-protective roles of SPINK6. Caffeic Acid Phenethyl Ester (CAPE) and Alpha-Lipoic Acid enhance SPINK6 by inhibiting pro-inflammatory pathways via NF-κB and bolstering cellular antioxidant defenses, respectively, which in turn supports the anti-proteolytic environment that SPINK6 upholds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea that can upregulate SPINK6 activity by inhibiting proteases that degrade extracellular matrix components, thus maintaining the integrity of the microenvironment where SPINK6 functions. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound in cruciferous vegetables that activates the Nrf2 pathway. By reducing oxidative stress in cells, it can enhance the function of SPINK6, which is involved in protecting tissues from proteolytic damage. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, the active compound in turmeric, has been shown to interact with multiple signaling pathways, including the inhibition of NF-κB. This action can lead to the indirect upregulation of SPINK6, enhancing its protective role against serine proteases. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a stilbenoid that activates sirtuin pathways, which can enhance SPINK6 activity by improving cell survival and function in stressful environments where SPINK6 is protective against proteolytic stress. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, has been shown to modulate the PI3K/Akt pathway, which indirectly could increase SPINK6 activity by promoting cellular resistance to proteolytic damage, an area where SPINK6 is active. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, regulates gene expression through retinoic acid receptors and may enhance SPINK6 activity by promoting differentiation processes in which SPINK6 is implicated. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3, through its receptor, can influence the expression of various proteins and could enhance SPINK6 activity by promoting cellular mechanisms that protect against protease imbalance. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential trace element that serves as a cofactor for many proteins. It can enhance SPINK6 activity indirectly by stabilizing molecular structures and functions where SPINK6 is protective against proteolytic stress. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene is a carotenoid with antioxidant properties that can enhance the functional activity of SPINK6 by reducing oxidative stress and promoting an environment that supports SPINK6's protease inhibitory role. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, found in certain fruits, acts as an antioxidant and has been shown to modulate inflammatory pathways, potentially enhancing SPINK6 activity by reducing inflammation-related proteolytic damage. | ||||||