Date published: 2025-10-18

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SphK Antibodies

Santa Cruz Biotechnology features a diverse variety of SphK monoclonal antibodies for research in sphingosine kinase signaling pathways. SphK monoclonal antibodies perform effectively in multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Sphingosine kinases (SphK1 and SphK2) regulate cellular processes such as proliferation, survival, and migration by controlling sphingosine-1-phosphate levels, a bioactive lipid mediator. Understanding SphK1 and SphK2 function has become increasingly important as research reveals their involvement in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Researchers can utilize specific SphK1 and SphK2 monoclonal antibodies to examine protein expression, localization, and interactions within cellular pathways. Advanced research techniques incorporating SphK monoclonal antibodies enable detailed analysis of sphingosine kinase activity in different tissue types and experimental conditions. Investigating sphingosine kinase signaling pathways provides valuable insights into potential therapeutic strategies for various diseases. Santa Cruz Biotechnology monoclonal antibodies for SphK research support scientists worldwide in advancing our understanding of fundamental cellular processes and developing new therapeutic approaches.

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SphK Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SphK1 Antibody (G-11)

sc-365401mouse IgG1 κ331-351 (m)WB, IP, IF, ELISAm, r, h
13
(8)

SphK2 Antibody (9C5E1)

sc-517192mouse IgG1 κ36-52 (h)IF, IHC(P), FCM, ELISAh
1
(0)

SphK CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SphK1 CRISPR/Cas9 KO Plasmid (h2)

sc-401274-KO-2hGene KnockoutGFP0
(0)

SphK1 HDR Plasmid (h2)

sc-401274-HDR-2hHomology Directed RepairPuromycin0
(0)

SphK1 Double Nickase Plasmid (h)

sc-401274-NIChGene KnockoutPuromycin0
(0)

SphK1 Double Nickase Plasmid (h2)

sc-401274-NIC-2hGene KnockoutPuromycin0
(0)

SphK1 CRISPR/Cas9 KO Plasmid (m)

sc-423102mGene KnockoutGFP0
(0)

SphK1 HDR Plasmid (m)

sc-423102-HDRmHomology Directed RepairPuromycin0
(0)

SphK1 Double Nickase Plasmid (m)

sc-423102-NICmGene KnockoutPuromycin0
(0)

SphK1 Double Nickase Plasmid (m2)

sc-423102-NIC-2mGene KnockoutPuromycin0
(0)

SphK2 CRISPR/Cas9 KO Plasmid (h)

sc-417921hGene KnockoutGFP0
(0)

SphK2 HDR Plasmid (h)

sc-417921-HDRhHomology Directed RepairPuromycin0
(0)

SphK2 Double Nickase Plasmid (h)

sc-417921-NIChGene KnockoutPuromycin0
(0)

SphK2 Double Nickase Plasmid (h2)

sc-417921-NIC-2hGene KnockoutPuromycin0
(0)

SphK2 CRISPR/Cas9 KO Plasmid (m)

sc-425246mGene KnockoutGFP0
(0)

SphK2 HDR Plasmid (m)

sc-425246-HDRmHomology Directed RepairPuromycin0
(0)

SphK2 Double Nickase Plasmid (m)

sc-425246-NICmGene KnockoutPuromycin0
(0)

SphK2 Double Nickase Plasmid (m2)

sc-425246-NIC-2mGene KnockoutPuromycin0
(0)

SphK CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SphK1 CRISPR Activation Plasmid (h)

sc-401274-ACThGene ActivationPuro, Blast, Hygro0
(0)

SphK1 CRISPR Activation Plasmid (h2)

sc-401274-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

SphK1 Lentiviral Activation Particles (h)

sc-401274-LAChGene ActivationPuro, Blast, Hygro0
(0)

SphK1 Lentiviral Activation Particles (h2)

sc-401274-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

SphK1 CRISPR Activation Plasmid (m)

sc-423102-ACTmGene ActivationPuro, Blast, Hygro0
(0)

SphK1 CRISPR Activation Plasmid (m2)

sc-423102-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

SphK1 Lentiviral Activation Particles (m)

sc-423102-LACmGene ActivationPuro, Blast, Hygro0
(0)

SphK1 Lentiviral Activation Particles (m2)

sc-423102-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

SphK2 CRISPR Activation Plasmid (h)

sc-417921-ACThGene ActivationPuro, Blast, Hygro0
(0)

SphK2 CRISPR Activation Plasmid (h2)

sc-417921-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

SphK2 Lentiviral Activation Particles (h)

sc-417921-LAChGene ActivationPuro, Blast, Hygro0
(0)

SphK2 Lentiviral Activation Particles (h2)

sc-417921-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

SphK2 CRISPR Activation Plasmid (m)

sc-425246-ACTmGene ActivationPuro, Blast, Hygro0
(0)

SphK2 CRISPR Activation Plasmid (m2)

sc-425246-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

SphK2 Lentiviral Activation Particles (m)

sc-425246-LACmGene ActivationPuro, Blast, Hygro0
(0)

SphK2 Lentiviral Activation Particles (m2)

sc-425246-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

SphK siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SphK1 siRNA (h)

sc-44114hGene SilencingN/A
17
(1)

SphK1 siRNA (h2)

sc-156038hGene SilencingN/A
2
(0)

SphK1 shRNA Plasmid (h)

sc-44114-SHhGene SilencingPuromycin
17
(1)

SphK1 shRNA Plasmid (h2)

sc-156038-SHhGene SilencingPuromycin
2
(0)

SphK1 shRNA (h) Lentiviral Particles

sc-44114-VhGene SilencingPuromycin
17
(1)

SphK1 shRNA (h2) Lentiviral Particles

sc-156038-VhGene SilencingPuromycin
2
(0)

SphK1 siRNA (m)

sc-45446mGene SilencingN/A
5
(1)

SphK1 shRNA Plasmid (m)

sc-45446-SHmGene SilencingPuromycin
5
(1)

SphK1 shRNA (m) Lentiviral Particles

sc-45446-VmGene SilencingPuromycin
5
(1)

SphK2 siRNA (h)

sc-39225hGene SilencingN/A
6
(1)

SphK2 shRNA Plasmid (h)

sc-39225-SHhGene SilencingPuromycin
6
(1)

SphK2 shRNA (h) Lentiviral Particles

sc-39225-VhGene SilencingPuromycin
6
(1)

SphK2 siRNA (m)

sc-39226mGene SilencingN/A
2
(1)

SphK2 shRNA Plasmid (m)

sc-39226-SHmGene SilencingPuromycin
2
(1)

SphK2 shRNA (m) Lentiviral Particles

sc-39226-VmGene SilencingPuromycin
2
(1)