SphK Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DL-threo-Dihydrosphingosine | 73938-69-9 | sc-201389 | 10 mg | $194.00 | 1 | |
DL-threo-Dihydrosphingosine functions as a sphingosine kinase (SphK) substrate, exhibiting distinct structural features that promote specific lipid interactions. Its dual hydroxyl groups enable robust hydrogen bonding, influencing membrane dynamics and cellular signaling pathways. The compound's unique stereochemistry enhances its affinity for lipid bilayers, facilitating rapid incorporation into sphingolipid metabolism. This specificity in molecular recognition plays a crucial role in modulating cellular responses and lipid homeostasis. | ||||||
Safingol | 15639-50-6 | sc-204258 | 1 mg | $235.00 | 1 | |
Safingol acts as a sphingosine kinase (SphK) inhibitor, characterized by its unique structural conformation that disrupts lipid signaling pathways. Its long hydrocarbon chain enhances hydrophobic interactions, allowing it to integrate into lipid membranes and alter their fluidity. The presence of a sphingoid backbone facilitates competitive binding to SphK, impacting enzyme kinetics and downstream signaling cascades. This modulation of lipid metabolism underscores its role in cellular regulation. | ||||||
D-erythro-N,N-Dimethylsphingosine | 119567-63-4 | sc-201373 sc-201373A | 5 mg 25 mg | $81.00 $316.00 | 1 | |
D-erythro-N,N-Dimethylsphingosine functions as a potent sphingosine kinase (SphK) inhibitor, distinguished by its dual methyl groups that enhance steric hindrance, thereby influencing enzyme-substrate interactions. Its unique configuration allows for selective binding, effectively modulating sphingolipid metabolism. The compound's hydrophobic nature promotes its incorporation into lipid bilayers, potentially altering membrane dynamics and impacting cellular signaling pathways through competitive inhibition. | ||||||
SKI II | 312636-16-1 | sc-204286 sc-204286A | 10 mg 50 mg | $96.00 $400.00 | 3 | |
SKI II is a selective inhibitor of sphingosine kinase, characterized by its unique structural features that facilitate specific interactions with the enzyme's active site. Its distinct molecular conformation allows for effective competition with sphingosine, influencing the kinetics of sphingolipid synthesis. The compound's amphipathic nature enhances its affinity for lipid environments, potentially disrupting membrane integrity and altering cellular signaling cascades through targeted inhibition of sphingolipid pathways. | ||||||
Sphingosine Kinase Inhibitor | 1177741-83-1 | sc-208400 | 10 mg | $149.00 | ||
Sphingosine Kinase Inhibitor exhibits a unique ability to modulate sphingosine kinase activity through its tailored binding interactions. This compound engages with the enzyme's regulatory sites, leading to altered reaction kinetics and downstream signaling effects. Its hydrophobic characteristics promote integration into lipid bilayers, potentially affecting membrane dynamics and cellular communication. By selectively disrupting sphingolipid metabolism, it influences various cellular processes and pathways. | ||||||
D-erythro-N,N-Dimethylsphingosine | 119567-63-4 | sc-211175 | 5 mg | $65.00 | ||
D-erythro-N,N-Dimethylsphingosine acts as a potent sphingosine kinase inhibitor, characterized by its specific affinity for the enzyme's active site. This compound alters the phosphorylation dynamics of sphingosine, impacting lipid signaling pathways. Its structural features facilitate unique interactions with membrane components, potentially influencing lipid raft formation and cellular compartmentalization. The compound's distinct hydrophobicity enhances its localization within lipid environments, further modulating cellular responses. | ||||||